C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: gap junction protein, alpha 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000068581 Gja1-201 ENSMUSG00000050953 10090 + 10:56377300-56390419 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000068581
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000068581 22.580±4.55 22.493±5.17 6.116±0.67 18.874±14.87 16.987±1.90 7.667±0.82 77.204±10.35 2.630±0.47 1.141±0.63 17.410±4.60 3.031±1.04 187.175±78.30 16.340±5.23 7.415±1.66

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001649 IMP osteoblast differentiation
GO:0001701 IMP in utero embryonic development
GO:0001764 IMP neuron migration
GO:0001937 IEA negative regulation of endothelial cell proliferation
GO:0001947 IMP heart looping
GO:0002070 IMP epithelial cell maturation
GO:0002088 IMP lens development in camera-type eye
GO:0002544 IEA chronic inflammatory response
GO:0003104 IEA positive regulation of glomerular filtration
GO:0003158 IEA endothelium development
GO:0003294 IGI atrial ventricular junction remodeling
GO:0003347 TAS epicardial cell to mesenchymal cell transition
GO:0004871 IEA signal transducer activity
GO:0005102 IPI receptor binding
GO:0005243 IDA gap junction channel activity
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005741 IEA mitochondrial outer membrane
GO:0005764 IEA lysosome
GO:0005768 IEA endosome
GO:0005769 IEA early endosome
GO:0005770 IEA late endosome
GO:0005771 IEA multivesicular body
GO:0005794 IDA Golgi apparatus
GO:0005829 IDA cytosol
GO:0005882 IDA intermediate filament
GO:0005886 IDA plasma membrane
GO:0005911 IDA cell-cell junction
GO:0005916 IDA fascia adherens
GO:0005921 IDA gap junction
GO:0005922 IEA connexon complex
GO:0005925 IEA focal adhesion
GO:0006915 IEA apoptotic process
GO:0007154 IEA cell communication
GO:0007165 IEA signal transduction
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007267 IDA cell-cell signaling
GO:0007507 IMP heart development
GO:0007512 IMP adult heart development
GO:0008016 IMP regulation of heart contraction
GO:0008285 IEA negative regulation of cell proliferation
GO:0009268 IEA response to pH
GO:0009749 IEA response to glucose
GO:0010232 IEA vascular transport
GO:0010628 IMP positive regulation of gene expression
GO:0010629 IMP negative regulation of gene expression
GO:0010643 IDA cell communication by chemical coupling
GO:0010644 IDA cell communication by electrical coupling
GO:0010652 IEA positive regulation of cell communication by chemical coupling
GO:0014704 IDA intercalated disc
GO:0015867 IEA ATP transport
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016324 IDA apical plasma membrane
GO:0016328 IDA lateral plasma membrane
GO:0017124 IEA SH3 domain binding
GO:0019904 IEA protein domain specific binding
GO:0030054 IDA cell junction
GO:0030165 IEA PDZ domain binding
GO:0030500 IMP regulation of bone mineralization
GO:0032024 IEA positive regulation of insulin secretion
GO:0034405 IEA response to fluid shear stress
GO:0035050 IMP embryonic heart tube development
GO:0042733 IMP embryonic digit morphogenesis
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043292 IDA contractile fiber
GO:0043403 IDA skeletal muscle tissue regeneration
GO:0043434 IEA response to peptide hormone
GO:0045121 IEA membrane raft
GO:0045216 IMP cell-cell junction organization
GO:0045669 IMP positive regulation of osteoblast differentiation
GO:0045732 IEA positive regulation of protein catabolic process
GO:0045844 IMP positive regulation of striated muscle tissue development
GO:0045907 IEA positive regulation of vasoconstriction
GO:0045909 IEA positive regulation of vasodilation
GO:0046850 IMP regulation of bone remodeling
GO:0048487 IDA beta-tubulin binding
GO:0048514 IMP blood vessel morphogenesis
GO:0048812 IEA neuron projection morphogenesis
GO:0051259 IEA protein oligomerization
GO:0051924 IEA regulation of calcium ion transport
GO:0055085 IEA transmembrane transport
GO:0060044 IEA negative regulation of cardiac muscle cell proliferation
GO:0060156 IMP milk ejection
GO:0060307 IGI regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060312 TAS regulation of blood vessel remodeling
GO:0060371 IMP regulation of atrial cardiac muscle cell membrane depolarization
GO:0060373 IGI regulation of ventricular cardiac muscle cell membrane depolarization
GO:0061045 IEA negative regulation of wound healing
GO:0061337 IMP cardiac conduction
GO:0070062 IEA extracellular vesicular exosome
GO:0071253 IEA connexin binding
GO:0071260 IEA cellular response to mechanical stimulus
GO:0090162 TAS establishment of epithelial cell polarity
GO:0097110 IPI scaffold protein binding
GO:2000279 IEA negative regulation of DNA biosynthetic process
GO:2000810 IEA regulation of tight junction assembly
GO:2000987 IEA positive regulation of behavioral fear response

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000061256 cx28.9-001 protein_coding Danio_rerio 0.00000000004 75
ENST00000282561 GJA1-001 protein_coding Homo_sapiens 0 2497
ENST00000415117 GJA6P-001 processed_pseudogene Homo_sapiens 0 427
ENST00000511478 GJA1P1-001 processed_pseudogene Homo_sapiens 0 1280

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