C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: adenosine A2a receptor
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000105420 Adora2a-201 ENSMUSG00000020178 10090 + 10:75316943-75334788 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000105420
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000105420 5.544±3.80 4.077±0.86 0.680±0.19 2.399±0.77 7.373±4.19 1.436±0.39 2.730±1.28 3.465±1.29 1.221±0.31 2.959±1.03 0.645±0.23 1.404±0.58 0.838±0.34 0.116±0.06

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006Z1 CIL_0006Z1_0003 CGP 10:75212073-75334788

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001609 IMP G-protein coupled adenosine receptor activity
GO:0001963 IGI synaptic transmission, dopaminergic
GO:0001973 IMP adenosine receptor signaling pathway
GO:0001975 IMP response to amphetamine
GO:0005515 IEA protein binding
GO:0005882 IEA intermediate filament
GO:0005886 IDA plasma membrane
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006469 IEA negative regulation of protein kinase activity
GO:0007186 IMP G-protein coupled receptor signaling pathway
GO:0007189 IMP adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007205 IEA protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007271 IEA synaptic transmission, cholinergic
GO:0007626 IGI locomotory behavior
GO:0008285 IEA negative regulation of cell proliferation
GO:0012505 IEA endomembrane system
GO:0014049 IEA positive regulation of glutamate secretion
GO:0014057 IEA positive regulation of acetylcholine secretion, neurotransmission
GO:0014061 IEA regulation of norepinephrine secretion
GO:0014069 IEA postsynaptic density
GO:0016020 IDA membrane
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0030673 IEA axolemma
GO:0030819 IDA positive regulation of cAMP biosynthetic process
GO:0031000 IEA response to caffeine
GO:0031802 IEA type 5 metabotropic glutamate receptor binding
GO:0032230 IDA positive regulation of synaptic transmission, GABAergic
GO:0032279 IEA asymmetric synapse
GO:0035249 IEA synaptic transmission, glutamatergic
GO:0035810 IEA positive regulation of urine volume
GO:0035815 IEA positive regulation of renal sodium excretion
GO:0040013 IEA negative regulation of locomotion
GO:0042311 IEA vasodilation
GO:0042493 IEA response to drug
GO:0042734 IEA presynaptic membrane
GO:0042755 IGI eating behavior
GO:0043025 IEA neuronal cell body
GO:0043116 IEA negative regulation of vascular permeability
GO:0043154 IEA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043279 IEA response to alkaloid
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0045211 IEA postsynaptic membrane
GO:0045938 IEA positive regulation of circadian sleep/wake cycle, sleep
GO:0046636 IDA negative regulation of alpha-beta T cell activation
GO:0046982 IEA protein heterodimerization activity
GO:0048143 IEA astrocyte activation
GO:0048167 IEA regulation of synaptic plasticity
GO:0048786 IEA presynaptic active zone
GO:0048812 IEA neuron projection morphogenesis
GO:0050714 IEA positive regulation of protein secretion
GO:0050728 IGI negative regulation of inflammatory response
GO:0051393 IEA alpha-actinin binding
GO:0051881 IEA regulation of mitochondrial membrane potential
GO:0051899 IEA membrane depolarization
GO:0051924 IEA regulation of calcium ion transport
GO:0051968 IEA positive regulation of synaptic transmission, glutamatergic
GO:0060079 IEA regulation of excitatory postsynaptic membrane potential
GO:0060080 IGI regulation of inhibitory postsynaptic membrane potential
GO:0060134 IEA prepulse inhibition
GO:2001235 IMP positive regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000337539 ADORA2A-001 protein_coding Homo_sapiens 0 1267
ENST00000358654 SPECC1L-ADORA2A-001 nonsense_mediated_decay Homo_sapiens 0 1267
ENST00000424232 ADORA2A-003 protein_coding Homo_sapiens 0 416
ENST00000436735 ADORA2A-015 protein_coding Homo_sapiens 0 320
ENST00000439591 ADORA2A-012 protein_coding Homo_sapiens 0 372
ENST00000444262 ADORA2A-005 protein_coding Homo_sapiens 0 1206
ENST00000472248 ADORA2A-011 protein_coding Homo_sapiens 6.02558e-44 182
ENST00000486108 ADORA2A-009 protein_coding Homo_sapiens 0 472
ENST00000496258 ADORA2A-002 protein_coding Homo_sapiens 0 394
ENST00000610595 SPECC1L-ADORA2A-201 protein_coding Homo_sapiens 0 1267
ENST00000611543 SPECC1L-ADORA2A-202 protein_coding Homo_sapiens 0 1267
ENST00000618076 SPECC1L-ADORA2A-203 protein_coding Homo_sapiens 0 1267

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