C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: neurofibromin 2 (merlin)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000338641 NF2-001 ENSG00000186575 9606 + 22:29603558-29698598 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastHeartKidneyLiverLungOvaryPlacentaTestisENST00000338641
Transcript ID Adipose Adrenal Brain Breast Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000338641 4.182±0.00 4.393±0.00 4.871±1.23 0.373±0.00 2.278±0.00 5.381±0.00 1.562±0.00 2.333±1.27 2.531±2.88 1.737±0.35 4.693±0.65

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001707 IEA mesoderm formation
GO:0001726 IEA ruffle
GO:0001953 TAS negative regulation of cell-matrix adhesion
GO:0003779 IEA actin binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005730 IDA nucleolus
GO:0005737 IDA:IEA cytoplasm
GO:0005769 IDA early endosome
GO:0005856 TAS:IEA cytoskeleton
GO:0005886 IDA plasma membrane
GO:0005912 IEA adherens junction
GO:0006469 IEA negative regulation of protein kinase activity
GO:0007398 IEA ectoderm development
GO:0007420 IEA brain development
GO:0008092 IEA cytoskeletal protein binding
GO:0008156 IMP negative regulation of DNA replication
GO:0008285 IDA negative regulation of cell proliferation
GO:0014010 IMP Schwann cell proliferation
GO:0016020 IDA membrane
GO:0019898 IEA extrinsic component of membrane
GO:0021766 IEA hippocampus development
GO:0022408 IDA negative regulation of cell-cell adhesion
GO:0030027 IEA lamellipodium
GO:0030036 IMP actin cytoskeleton organization
GO:0030175 IEA filopodium
GO:0030336 TAS negative regulation of cell migration
GO:0030864 IEA cortical actin cytoskeleton
GO:0031647 IEA regulation of protein stability
GO:0032154 IEA cleavage furrow
GO:0035330 IMP regulation of hippo signaling
GO:0042127 IEA regulation of cell proliferation
GO:0042475 IEA odontogenesis of dentin-containing tooth
GO:0042518 IDA negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0042524 IDA negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0043409 IEA negative regulation of MAPK cascade
GO:0045177 IEA apical part of cell
GO:0045216 IEA cell-cell junction organization
GO:0045597 IEA positive regulation of cell differentiation
GO:0046426 IDA negative regulation of JAK-STAT cascade
GO:0048471 IDA perinuclear region of cytoplasm
GO:0051496 IMP positive regulation of stress fiber assembly
GO:0070306 IEA lens fiber cell differentiation
GO:1900180 IEA regulation of protein localization to nucleus
GO:2000177 IEA regulation of neural precursor cell proliferation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000109910 Nf2-001 protein_coding Mus_musculus 0 2571
ENSMUST00000053079 Nf2-004 protein_coding Mus_musculus 0 2436
ENSMUST00000056290 Nf2-002 protein_coding Mus_musculus 0 2261
ENSMUST00000109908 Nf2-003 processed_transcript Mus_musculus 0 2093
ENSMUST00000093374 Nf2-013 protein_coding Mus_musculus 0 1956
ENSMUST00000155600 Nf2-006 processed_transcript Mus_musculus 0 784
ENSMUST00000124878 Nf2-005 nonsense_mediated_decay Mus_musculus 0 520
ENSMUST00000164190 Nf2-007 protein_coding Mus_musculus 0 516
ENSMUST00000152656 Nf2-008 nonsense_mediated_decay Mus_musculus 0 496
ENSMUST00000137926 Nf2-012 protein_coding Mus_musculus 0 462
ENSMUST00000141342 Nf2-009 retained_intron Mus_musculus 0 424
ENSMUST00000167480 Nf2-011 processed_transcript Mus_musculus 0 353
ENSMUST00000172305 Nf2-010 protein_coding Mus_musculus 0 268

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