C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: hes family bHLH transcription factor 5
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000378453 HES5-001 ENSG00000197921 9606 - 1:2528745-2530245 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000378453
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000378453 0.051±0.00 0.215±0.00 0.660±0.49 0.151±0.00 0.285±0.12 0.240±0.00 0.059±0.00 0.206±0.00 0.282±0.00 0.097±0.00 0.224±0.01 0.271±0.17 0.605±0.12

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0001078 ISS RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003690 IEA double-stranded DNA binding
GO:0005515 IEA protein binding
GO:0005575 ND cellular_component
GO:0005654 TAS nucleoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006461 ISS protein complex assembly
GO:0007155 ISS cell adhesion
GO:0007219 IMP Notch signaling pathway
GO:0007224 ISS smoothened signaling pathway
GO:0007420 ISS brain development
GO:0008134 NAS transcription factor binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0014003 ISS oligodendrocyte development
GO:0021537 ISS telencephalon development
GO:0021781 ISS glial cell fate commitment
GO:0021861 IEA forebrain radial glial cell differentiation
GO:0021915 ISS neural tube development
GO:0022010 ISS central nervous system myelination
GO:0030182 IEA neuron differentiation
GO:0030513 ISS positive regulation of BMP signaling pathway
GO:0031641 ISS regulation of myelination
GO:0042491 ISS auditory receptor cell differentiation
GO:0042517 ISS positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042668 IEA auditory receptor cell fate determination
GO:0043010 ISS camera-type eye development
GO:0045595 ISS regulation of cell differentiation
GO:0045665 ISS negative regulation of neuron differentiation
GO:0045747 IEA positive regulation of Notch signaling pathway
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046427 ISS positive regulation of JAK-STAT cascade
GO:0046983 IEA protein dimerization activity
GO:0048469 ISS cell maturation
GO:0048661 IGI positive regulation of smooth muscle cell proliferation
GO:0048708 ISS astrocyte differentiation
GO:0048712 ISS negative regulation of astrocyte differentiation
GO:0048715 ISS negative regulation of oligodendrocyte differentiation
GO:0050767 ISS regulation of neurogenesis
GO:0051216 IDA cartilage development
GO:0072049 IEA comma-shaped body morphogenesis
GO:0072050 IEA S-shaped body morphogenesis
GO:0072086 IEA specification of loop of Henle identity
GO:0072282 IEA metanephric nephron tubule morphogenesis
GO:0097150 IEP neuronal stem cell maintenance
GO:2000737 IMP negative regulation of stem cell differentiation
GO:2000974 ISS negative regulation of pro-B cell differentiation
GO:2000978 IEA negative regulation of forebrain neuron differentiation
GO:2000981 IEA negative regulation of inner ear receptor cell differentiation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000049621 Hes5-001 protein_coding Mus_musculus 0 1042
ENSMUST00000151480 Hes5-003 processed_transcript Mus_musculus 0 351

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