C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: eukaryotic translation initiation factor 2-alpha kinase 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000395127 EIF2AK2-201 ENSG00000055332 9606 - 2:37105143-37157047 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBreastColonHeartKidneyENST00000395127
Transcript ID Bladder Breast Colon Heart Kidney
ENST00000395127 1.507±0.00 2.403±0.00 2.324±0.00 0.843±0.00 3.583±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000MW CIL_0000MW_0001 CGP 2:36968383-37099244
CIL_0000N3 CIL_0000N3_0001 CGP 2:37084451-37157065
CIL_0000N4 CIL_0000N4_0001 CGP 2:37099210-37196598

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000186 IMP activation of MAPKK activity
GO:0001819 ISS positive regulation of cytokine production
GO:0003725 IDA double-stranded RNA binding
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 TAS protein serine/threonine kinase activity
GO:0004694 TAS eukaryotic translation initiation factor 2alpha kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006468 IDA:IEA protein phosphorylation
GO:0008285 TAS negative regulation of cell proliferation
GO:0008601 TAS protein phosphatase type 2A regulator activity
GO:0009615 IMP response to virus
GO:0016020 IDA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017148 IDA negative regulation of translation
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019048 TAS modulation by virus of host morphology or physiology
GO:0019054 TAS modulation by virus of host process
GO:0019058 TAS viral life cycle
GO:0030683 TAS evasion or tolerance by virus of host immune response
GO:0032722 ISS positive regulation of chemokine production
GO:0032874 ISS positive regulation of stress-activated MAPK cascade
GO:0033689 IMP negative regulation of osteoblast proliferation
GO:0035455 IDA response to interferon-alpha
GO:0044822 IDA poly(A) RNA binding
GO:0045071 IMP negative regulation of viral genome replication
GO:0045087 IEA innate immune response
GO:0046777 IMP protein autophosphorylation
GO:0048471 IDA perinuclear region of cytoplasm
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051607 IEA defense response to virus
GO:1900225 ISS regulation of NLRP3 inflammasome complex assembly
GO:1901224 ISS positive regulation of NIK/NF-kappaB signaling
GO:1901532 ISS regulation of hematopoietic progenitor cell differentiation
GO:1902033 ISS regulation of hematopoietic stem cell proliferation
GO:1902036 ISS regulation of hematopoietic stem cell differentiation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000034431 Tmem170-201 protein_coding Mus_musculus 0.000002 60

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