C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: protein kinase, AMP-activated, alpha 1 catalytic subunit
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000397128 PRKAA1-002 ENSG00000132356 9606 - 5:40759379-40798198 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000397128
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000397128 13.353±0.00 9.653±0.00 8.976±0.00 5.505±0.06 8.528±0.00 1.187±0.00 4.716±0.91 10.442±1.52 9.180±0.38 13.016±2.82 2.475±0.85 9.600±2.85 3.493±0.28 5.429±2.28

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000187 NAS activation of MAPK activity
GO:0001666 NAS response to hypoxia
GO:0003682 ISS chromatin binding
GO:0004672 IDA:IEA protein kinase activity
GO:0004679 IDA AMP-activated protein kinase activity
GO:0004691 NAS cAMP-dependent protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005622 IC intracellular
GO:0005634 ISS nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006468 IDA:IEA protein phosphorylation
GO:0006633 IEA fatty acid biosynthetic process
GO:0006695 IEA cholesterol biosynthetic process
GO:0006914 IEA autophagy
GO:0007050 TAS cell cycle arrest
GO:0007165 TAS signal transduction
GO:0008286 TAS insulin receptor signaling pathway
GO:0008610 ISS lipid biosynthetic process
GO:0010332 ISS response to gamma radiation
GO:0010508 ISS positive regulation of autophagy
GO:0010628 IDA positive regulation of gene expression
GO:0016055 IEA Wnt signaling pathway
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0031588 ISS AMP-activated protein kinase complex
GO:0031669 ISS cellular response to nutrient levels
GO:0032007 ISS negative regulation of TOR signaling
GO:0035174 ISS histone serine kinase activity
GO:0042149 ISS cellular response to glucose starvation
GO:0042593 ISS glucose homeostasis
GO:0042752 ISS regulation of circadian rhythm
GO:0043066 ISS negative regulation of apoptotic process
GO:0045542 NAS positive regulation of cholesterol biosynthetic process
GO:0045821 ISS positive regulation of glycolytic process
GO:0046318 NAS negative regulation of glucosylceramide biosynthetic process
GO:0046872 IEA metal ion binding
GO:0047322 IEA [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO:0048511 IEA rhythmic process
GO:0050321 IEA tau-protein kinase activity
GO:0050405 IEA [acetyl-CoA carboxylase] kinase activity
GO:0050995 ISS negative regulation of lipid catabolic process
GO:0055089 ISS fatty acid homeostasis
GO:2000505 ISS regulation of energy homeostasis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000051186 Prkaa1-201 protein_coding Mus_musculus 0 2410
ENSMUST00000053033 D1Ertd622e-001 protein_coding Mus_musculus 0.0000000009 71

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