C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: insulin
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000397262 INS-003 ENSG00000254647 9606 - 11:2159779-2161204 protein_coding

Expression Patterns

No expression data.

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008MR CIL_0008MR_0001 VISTA 11:1663842-2266142
CIL_0007RG CIL_0007RG_0001 VISTA 11:1668349-2271510
CIL_00097V CIL_00097V_0001 VISTA 11:1688064-2293510
CIL_0009BT CIL_0009BT_0001 VISTA 11:2074187-2675527
CIL_0008VI CIL_0008VI_0001 VISTA 11:2150916-2751083

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000165 IDA MAPK cascade
GO:0002020 IPI protease binding
GO:0002674 IDA negative regulation of acute inflammatory response
GO:0005158 IDA insulin receptor binding
GO:0005159 IPI insulin-like growth factor receptor binding
GO:0005179 NAS:IEA hormone activity
GO:0005515 IPI protein binding
GO:0005576 IC:IEA extracellular region
GO:0005615 IDA extracellular space
GO:0005788 TAS endoplasmic reticulum lumen
GO:0005796 TAS Golgi lumen
GO:0006006 IEA glucose metabolic process
GO:0006112 TAS energy reserve metabolic process
GO:0006355 NAS regulation of transcription, DNA-templated
GO:0006521 IMP regulation of cellular amino acid metabolic process
GO:0006953 IDA acute-phase response
GO:0007186 IDA G-protein coupled receptor signaling pathway
GO:0007267 IC cell-cell signaling
GO:0008284 IDA positive regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0014068 IDA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015758 IDA glucose transport
GO:0022898 IDA regulation of transmembrane transporter activity
GO:0030307 NAS positive regulation of cell growth
GO:0030335 ISS positive regulation of cell migration
GO:0031018 TAS endocrine pancreas development
GO:0031904 TAS endosome lumen
GO:0031954 ISS positive regulation of protein autophosphorylation
GO:0032148 IDA activation of protein kinase B activity
GO:0032270 IMP positive regulation of cellular protein metabolic process
GO:0032460 IDA negative regulation of protein oligomerization
GO:0032880 IDA regulation of protein localization
GO:0033861 IDA negative regulation of NAD(P)H oxidase activity
GO:0034774 TAS secretory granule lumen
GO:0042060 IDA wound healing
GO:0042177 IDA negative regulation of protein catabolic process
GO:0042593 IMP glucose homeostasis
GO:0042802 IPI identical protein binding
GO:0043410 IDA positive regulation of MAPK cascade
GO:0044267 TAS cellular protein metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045429 NAS positive regulation of nitric oxide biosynthetic process
GO:0045597 NAS positive regulation of cell differentiation
GO:0045721 NAS negative regulation of gluconeogenesis
GO:0045725 IDA positive regulation of glycogen biosynthetic process
GO:0045740 IDA positive regulation of DNA replication
GO:0045818 IMP negative regulation of glycogen catabolic process
GO:0045821 IMP positive regulation of glycolytic process
GO:0045840 IDA positive regulation of mitosis
GO:0045861 IMP negative regulation of proteolysis
GO:0045908 NAS negative regulation of vasodilation
GO:0045909 NAS positive regulation of vasodilation
GO:0045922 IMP negative regulation of fatty acid metabolic process
GO:0046326 IDA positive regulation of glucose import
GO:0046628 IDA positive regulation of insulin receptor signaling pathway
GO:0046631 IDA alpha-beta T cell activation
GO:0046889 NAS positive regulation of lipid biosynthetic process
GO:0050708 IDA regulation of protein secretion
GO:0050709 IDA negative regulation of protein secretion
GO:0050715 IDA positive regulation of cytokine secretion
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050796 TAS regulation of insulin secretion
GO:0050995 NAS negative regulation of lipid catabolic process
GO:0051000 NAS positive regulation of nitric-oxide synthase activity
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0055089 IMP fatty acid homeostasis
GO:0060266 IDA negative regulation of respiratory burst involved in inflammatory response
GO:0060267 IDA positive regulation of respiratory burst
GO:0090277 TAS positive regulation of peptide hormone secretion
GO:0090336 TAS positive regulation of brown fat cell differentiation
GO:1902176 NAS negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000252 IDA negative regulation of feeding behavior

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000105933 Ins2-002 protein_coding Mus_musculus 0 313
ENSMUST00000105932 Ins2-005 protein_coding Mus_musculus 0 311
ENSMUST00000000220 Ins2-001 protein_coding Mus_musculus 0 311
ENSMUST00000105934 Ins2-006 protein_coding Mus_musculus 0 311
ENSMUST00000039652 Ins1-201 protein_coding Mus_musculus 0 267
ENSMUST00000105930 Ins2-004 protein_coding Mus_musculus 2e-38 163
ENSMUST00000105931 Ins2-003 protein_coding Mus_musculus 2e-38 163
ENSMUST00000162317 Ins2-008 protein_coding Mus_musculus 8e-32 141

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