C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: major histocompatibility complex, class II, DR beta 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000419393 HLA-DRB1-001 ENSG00000228080 9606 - CHR_HSCHR6_MHC_SSTO_CTG1:32670593-32685299 protein_coding

Expression Patterns

No expression data.

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0002381 ISS immunoglobulin production involved in immunoglobulin mediated immune response
GO:0002437 IDA inflammatory response to antigenic stimulus
GO:0002455 ISS humoral immune response mediated by circulating immunoglobulin
GO:0002503 IDA peptide antigen assembly with MHC class II protein complex
GO:0002862 IDA negative regulation of inflammatory response to antigenic stimulus
GO:0005515 IPI:IEA protein binding
GO:0005765 IDA lysosomal membrane
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006955 ISS:IEA immune response
GO:0007165 NAS signal transduction
GO:0009897 ISS external side of plasma membrane
GO:0012507 TAS ER to Golgi transport vesicle membrane
GO:0016020 IEA membrane
GO:0016045 ISS detection of bacterium
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019882 IEA antigen processing and presentation
GO:0019886 TAS antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030658 TAS transport vesicle membrane
GO:0030666 TAS endocytic vesicle membrane
GO:0030669 TAS clathrin-coated endocytic vesicle membrane
GO:0031295 TAS T cell costimulation
GO:0031902 IDA late endosome membrane
GO:0032395 TAS MHC class II receptor activity
GO:0032588 TAS trans-Golgi network membrane
GO:0032673 ISS regulation of interleukin-4 production
GO:0032689 ISS negative regulation of interferon-gamma production
GO:0035774 ISS positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042088 ISS T-helper 1 type immune response
GO:0042130 ISS negative regulation of T cell proliferation
GO:0042605 ISS peptide antigen binding
GO:0042613 IEA:IDA MHC class II protein complex
GO:0050852 TAS T cell receptor signaling pathway
GO:0051262 ISS protein tetramerization
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0071556 TAS integral component of lumenal side of endoplasmic reticulum membrane
GO:2001179 ISS regulation of interleukin-10 secretion

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000074557 H2-Eb1-001 protein_coding Mus_musculus 0 706

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