C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: interleukin 10
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000423557 IL10-001 ENSG00000136634 9606 - 1:206767602-206772494 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000423557
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000423557 0.701±0.00 1.360±0.00 0.218±0.00 0.121±0.08 0.248±0.00 0.352±0.00 0.101±0.01 0.359±0.00 0.247±0.00 0.300±0.11 0.149±0.00 0.183±0.16 0.623±0.10 0.216±0.03

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001818 IEA negative regulation of cytokine production
GO:0002237 IDA response to molecule of bacterial origin
GO:0002740 IDA negative regulation of cytokine secretion involved in immune response
GO:0002875 IEA negative regulation of chronic inflammatory response to antigenic stimulus
GO:0002904 IDA positive regulation of B cell apoptotic process
GO:0005125 NAS cytokine activity
GO:0005141 NAS interleukin-10 receptor binding
GO:0005615 IDA extracellular space
GO:0006954 IDA inflammatory response
GO:0006955 IEA immune response
GO:0007253 NAS cytoplasmic sequestering of NF-kappaB
GO:0007267 IC cell-cell signaling
GO:0007568 IEA aging
GO:0008083 NAS growth factor activity
GO:0010033 IEA response to organic substance
GO:0010468 IDA regulation of gene expression
GO:0014823 IEA response to activity
GO:0014854 IEA response to inactivity
GO:0030097 TAS hemopoiesis
GO:0030183 NAS B cell differentiation
GO:0030595 TAS leukocyte chemotaxis
GO:0030886 IEA negative regulation of myeloid dendritic cell activation
GO:0030889 IDA negative regulation of B cell proliferation
GO:0032496 IEA response to lipopolysaccharide
GO:0032689 IEA negative regulation of interferon-gamma production
GO:0032695 IEA negative regulation of interleukin-12 production
GO:0032715 IDA negative regulation of interleukin-6 production
GO:0032720 IEA negative regulation of tumor necrosis factor production
GO:0032800 IDA receptor biosynthetic process
GO:0032868 IEA response to insulin
GO:0034465 IEA response to carbon monoxide
GO:0042092 TAS type 2 immune response
GO:0042100 NAS B cell proliferation
GO:0042130 NAS negative regulation of T cell proliferation
GO:0042493 IEA response to drug
GO:0042536 IEA negative regulation of tumor necrosis factor biosynthetic process
GO:0042742 IEA defense response to bacterium
GO:0043066 NAS negative regulation of apoptotic process
GO:0044130 IEA negative regulation of growth of symbiont in host
GO:0045019 IEA negative regulation of nitric oxide biosynthetic process
GO:0045191 NAS regulation of isotype switching
GO:0045347 TAS negative regulation of MHC class II biosynthetic process
GO:0045348 IEA positive regulation of MHC class II biosynthetic process
GO:0045355 NAS negative regulation of interferon-alpha biosynthetic process
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0050715 IDA positive regulation of cytokine secretion
GO:0050728 IEA negative regulation of inflammatory response
GO:0051045 IDA negative regulation of membrane protein ectodomain proteolysis
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384 IDA response to glucocorticoid
GO:0051930 IEA regulation of sensory perception of pain
GO:0060670 IEA branching involved in labyrinthine layer morphogenesis
GO:0071222 NAS cellular response to lipopolysaccharide
GO:0071392 IEA cellular response to estradiol stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000016673 Il10-001 protein_coding Mus_musculus 0 638

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