C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Wolfram syndrome 1 (wolframin)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000503569 WFS1-008 ENSG00000109501 9606 + 4:6269849-6302883 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000503569
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000503569 19.442±0.00 2.672±0.00 0.931±0.00 6.510±5.16 8.691±7.35 3.684±2.83 6.504±5.91 0.934±0.00 1.989±1.07 10.725±0.00 2.871±0.00 14.651±17.02 7.314±1.41 8.607±2.74

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003E5 CIL_0003E5_0002 CGP 4:6026199-6303265

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001822 IMP kidney development
GO:0003091 IMP renal water homeostasis
GO:0005215 ISS transporter activity
GO:0005783 ISS endoplasmic reticulum
GO:0005789 TAS endoplasmic reticulum membrane
GO:0006983 IC ER overload response
GO:0006987 TAS activation of signaling protein activity involved in unfolded protein response
GO:0007601 IMP visual perception
GO:0007605 IMP sensory perception of sound
GO:0022417 IC protein maturation by protein folding
GO:0030176 IDA integral component of endoplasmic reticulum membrane
GO:0030425 ISS dendrite
GO:0030433 ISS ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 ISS endoplasmic reticulum unfolded protein response
GO:0031398 ISS positive regulation of protein ubiquitination
GO:0031625 ISS ubiquitin protein ligase binding
GO:0032469 IDA endoplasmic reticulum calcium ion homeostasis
GO:0033613 ISS activating transcription factor binding
GO:0034976 IDA response to endoplasmic reticulum stress
GO:0042593 IMP glucose homeostasis
GO:0043069 IMP negative regulation of programmed cell death
GO:0043433 ISS negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0044267 TAS cellular protein metabolic process
GO:0045862 ISS positive regulation of proteolysis
GO:0045927 ISS positive regulation of growth
GO:0050821 ISS protein stabilization
GO:0050877 IMP neurological system process
GO:0051117 IPI ATPase binding
GO:0051247 IDA positive regulation of protein metabolic process
GO:0051928 IDA positive regulation of calcium ion transport
GO:0055074 IDA calcium ion homeostasis
GO:0070845 ISS polyubiquitinated misfolded protein transport
GO:1902236 ISS negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:2000675 IMP negative regulation of type B pancreatic cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000043964 Wfs1-001 protein_coding Mus_musculus 0 2700
ENSMUST00000166339 Wfs1-002 protein_coding Mus_musculus 0 1744
ENSMUST00000167937 Wfs1-003 nonsense_mediated_decay Mus_musculus 0 496

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