C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: purinergic receptor P2X, ligand-gated ion channel, 7
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000535600 P2RX7-005 ENSG00000089041 9606 + 12:121132971-121184802 nonsense_mediated_decay

Expression Patterns

No expression data.

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002ZL CIL_0002ZL_0001 CGP 12:121132819-121234106

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001530 ISS lipopolysaccharide binding
GO:0001614 IDA:IEA purinergic nucleotide receptor activity
GO:0002028 ISS regulation of sodium ion transport
GO:0004931 IDA extracellular ATP-gated cation channel activity
GO:0005102 ISS receptor binding
GO:0005216 IEA ion channel activity
GO:0005524 IC:IEA ATP binding
GO:0005639 IBA integral component of nuclear inner membrane
GO:0005737 ISS cytoplasm
GO:0005886 ISS plasma membrane
GO:0005887 IC integral component of plasma membrane
GO:0006811 IEA ion transport
GO:0006812 IDA cation transport
GO:0007166 ISS cell surface receptor signaling pathway
GO:0010524 IDA positive regulation of calcium ion transport into cytosol
GO:0016020 IDA:IEA membrane
GO:0019233 ISS sensory perception of pain
GO:0030501 ISS positive regulation of bone mineralization
GO:0032059 ISS bleb
GO:0032060 ISS bleb assembly
GO:0033198 IDA response to ATP
GO:0035590 IEA purinergic nucleotide receptor signaling pathway
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042803 NAS protein homodimerization activity
GO:0043409 ISS negative regulation of MAPK cascade
GO:0045087 TAS innate immune response
GO:0045779 ISS negative regulation of bone resorption
GO:0045919 ISS positive regulation of cytolysis
GO:0046931 IDA pore complex assembly
GO:0050718 IDA positive regulation of interleukin-1 beta secretion
GO:0051495 ISS positive regulation of cytoskeleton organization
GO:0051709 NAS regulation of killing of cells of other organism
GO:0051899 IDA membrane depolarization
GO:0097190 ISS apoptotic signaling pathway
GO:0098655 IDA cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000100737 P2rx7-001 protein_coding Mus_musculus 0 584
ENSMUST00000031425 P2rx7-003 protein_coding Mus_musculus 0 564
ENSMUST00000121489 P2rx7-002 protein_coding Mus_musculus 0 564
ENSMUST00000086247 P2rx7-004 protein_coding Mus_musculus 0 363

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