C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: v-akt murine thymoma viral oncogene homolog 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000554581 AKT1-005 ENSG00000142208 9606 - 14:104769349-104794124 protein_coding

Expression Patterns

No expression data.

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001G0 CIL_0001G0_0001 CGP 14:104753100-104795751
CIL_00030T CIL_00030T_0001 CGP 14:104769349-104804712

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000060 IMP protein import into nucleus, translocation
GO:0001649 IEA osteoblast differentiation
GO:0001893 IEA maternal placenta development
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0001938 IMP positive regulation of endothelial cell proliferation
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IDA:IEA protein serine/threonine kinase activity
GO:0004712 IDA protein serine/threonine/tyrosine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005080 IEA protein kinase C binding
GO:0005515 IPI protein binding
GO:0005524 IC:IEA ATP binding
GO:0005547 IDA phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 ISS cytoplasm
GO:0005739 IEA mitochondrion
GO:0005819 IEA spindle
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0005911 IEA cell-cell junction
GO:0005977 IEA glycogen metabolic process
GO:0005978 IEA glycogen biosynthetic process
GO:0005979 IMP regulation of glycogen biosynthetic process
GO:0006006 IEA glucose metabolic process
GO:0006412 IEA translation
GO:0006417 IEA regulation of translation
GO:0006464 TAS cellular protein modification process
GO:0006468 IDA:IEA protein phosphorylation
GO:0006469 ISS negative regulation of protein kinase activity
GO:0006809 TAS nitric oxide biosynthetic process
GO:0006915 TAS apoptotic process
GO:0006924 IMP activation-induced cell death of T cells
GO:0006954 IEA inflammatory response
GO:0006979 ISS response to oxidative stress
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0007281 IEA germ cell development
GO:0007568 IEA aging
GO:0007596 TAS blood coagulation
GO:0008283 TAS cell proliferation
GO:0008286 IMP insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0008637 IEA apoptotic mitochondrial changes
GO:0009408 TAS response to heat
GO:0009725 IEA response to hormone
GO:0010467 TAS gene expression
GO:0010507 IMP negative regulation of autophagy
GO:0010748 IMP negative regulation of plasma membrane long-chain fatty acid transport
GO:0010765 IEA positive regulation of sodium ion transport
GO:0010907 IMP positive regulation of glucose metabolic process
GO:0010951 IMP negative regulation of endopeptidase activity
GO:0010975 ISS regulation of neuron projection development
GO:0015630 IDA microtubule cytoskeleton
GO:0015758 IEA glucose transport
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0016301 IDA kinase activity
GO:0016310 IDA phosphorylation
GO:0016567 IEA protein ubiquitination
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0019899 ISS enzyme binding
GO:0019901 IEA protein kinase binding
GO:0030030 IEA cell projection organization
GO:0030154 TAS cell differentiation
GO:0030163 IEA protein catabolic process
GO:0030168 TAS platelet activation
GO:0030212 IEA hyaluronan metabolic process
GO:0030235 IMP nitric-oxide synthase regulator activity
GO:0030307 IDA positive regulation of cell growth
GO:0030334 IMP regulation of cell migration
GO:0031018 TAS endocrine pancreas development
GO:0031295 TAS T cell costimulation
GO:0031641 IEA regulation of myelination
GO:0031659 IDA positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0031999 IMP negative regulation of fatty acid beta-oxidation
GO:0032094 IEA response to food
GO:0032270 ISS positive regulation of cellular protein metabolic process
GO:0032287 IEA peripheral nervous system myelin maintenance
GO:0032436 IEA positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032869 ISS cellular response to insulin stimulus
GO:0032880 IEA regulation of protein localization
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0034405 IMP response to fluid shear stress
GO:0035556 IDA intracellular signal transduction
GO:0036064 IEA ciliary basal body
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042593 IEA glucose homeostasis
GO:0042802 IPI identical protein binding
GO:0043065 IEA positive regulation of apoptotic process
GO:0043066 IDA negative regulation of apoptotic process
GO:0043154 ISS negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043325 IDA phosphatidylinositol-3,4-bisphosphate binding
GO:0043491 IEA protein kinase B signaling
GO:0043536 IDA positive regulation of blood vessel endothelial cell migration
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0045429 IMP positive regulation of nitric oxide biosynthetic process
GO:0045600 IMP positive regulation of fat cell differentiation
GO:0045725 IMP positive regulation of glycogen biosynthetic process
GO:0045792 IEA negative regulation of cell size
GO:0045861 IMP negative regulation of proteolysis
GO:0045907 IEA positive regulation of vasoconstriction
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046209 TAS nitric oxide metabolic process
GO:0046326 IMP positive regulation of glucose import
GO:0046329 IEA negative regulation of JNK cascade
GO:0046777 TAS protein autophosphorylation
GO:0046889 IMP positive regulation of lipid biosynthetic process
GO:0048009 IMP insulin-like growth factor receptor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0050999 TAS regulation of nitric-oxide synthase activity
GO:0051000 IMP positive regulation of nitric-oxide synthase activity
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051146 IEA striated muscle cell differentiation
GO:0060644 TAS mammary gland epithelial cell differentiation
GO:0060709 IEA glycogen cell differentiation involved in embryonic placenta development
GO:0060716 IEA labyrinthine layer blood vessel development
GO:0061024 TAS membrane organization
GO:0070141 IDA response to UV-A
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071364 IEA cellular response to epidermal growth factor stimulus
GO:0071407 IEA cellular response to organic cyclic compound
GO:0071456 IEA cellular response to hypoxia
GO:0071889 IPI 14-3-3 protein binding
GO:0090004 IMP positive regulation of establishment of protein localization to plasma membrane
GO:0090201 ISS negative regulation of release of cytochrome c from mitochondria
GO:0097011 IEA cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:0097194 IEA execution phase of apoptosis
GO:1900740 TAS positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901215 NAS negative regulation of neuron death
GO:1901653 IEA cellular response to peptide
GO:1901976 TAS regulation of cell cycle checkpoint
GO:1902176 NAS negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2001240 TAS negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000001780 Akt1-001 protein_coding Mus_musculus 0 1958
ENSMUST00000128300 Akt1-006 protein_coding Mus_musculus 0 1109
ENSMUST00000123563 Akt1-008 retained_intron Mus_musculus 0 857
ENSMUST00000144550 Akt1-002 protein_coding Mus_musculus 0 789
ENSMUST00000130342 Akt1-003 protein_coding Mus_musculus 0 505
ENSMUST00000127588 Akt1-007 retained_intron Mus_musculus 0 392
ENSMUST00000159815 Akt1-009 retained_intron Mus_musculus 0 377
ENSMUST00000139388 Akt1-004 processed_transcript Mus_musculus 0 315
ENSMUST00000127902 Akt1-005 processed_transcript Mus_musculus 1.4013e-45 189

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