C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: signal peptide peptidase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSDARG00000025220 sppl3 7955 + 10:17359362-17464927 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSDART00000038780 sppl3-201 17359362-17464098 protein_coding
  ENSDART00000122663 sppl3-202 17402447-17464927 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainHeartKidneyLiverMuscleENSDART00000122663
Transcript ID Brain Heart Kidney Liver Muscle
ENSDART00000122663 13.776±10.66 4.589±5.55 3.553±1.41 0.740±0.00 4.765±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004190 IEA aspartic-type endopeptidase activity
GO:0005791 ISS rough endoplasmic reticulum
GO:0016021 IEA integral to membrane
GO:0030660 ISS Golgi-associated vesicle membrane
GO:0042500 ISS aspartic endopeptidase activity, intramembrane cleaving
GO:0042803 ISS protein homodimerization activity
GO:0043523 IMP regulation of neuron apoptotic process
GO:0071458 ISS integral to cytosolic side of endoplasmic reticulum membrane
GO:0071556 ISS integral to lumenal side of endoplasmic reticulum membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000157837 SPPL3 signal peptide peptidase like 3 protein_coding Homo_sapiens
ENSMUSG00000029550 Sppl3 signal peptide peptidase 3 protein_coding Mus_musculus

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