C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSDARG00000025948 mlh1 7955 + 13:43255387-43270620 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSDART00000133388 mlh1-001 43255387-43270620 protein_coding
  ENSDART00000147996 mlh1-002 43255390-43259892 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainHeartKidneyLiverENSDART00000133388ENSDART00000147996
Transcript ID Brain Heart Kidney Liver
ENSDART00000133388 1.783±0.87 1.283±0.00 0.927±0.00 0.239±0.00
ENSDART00000147996 3.254±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00041G CIL_00041G_0001 CGP 13:43255387-43326974

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000795 IBA synaptonemal complex
GO:0003697 IBA single-stranded DNA binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005712 IBA chiasma
GO:0006200 IBA ATP catabolic process
GO:0006298 IEA mismatch repair
GO:0007059 IMP chromosome segregation
GO:0007131 IBA reciprocal meiotic recombination
GO:0007141 IMP male meiosis I
GO:0007283 IMP spermatogenesis
GO:0016446 IBA somatic hypermutation of immunoglobulin genes
GO:0016887 IBA ATPase activity
GO:0030983 IEA mismatched DNA binding
GO:0032300 IBA mismatch repair complex
GO:0032389 IBA MutLalpha complex
GO:0032390 IBA MutLbeta complex
GO:0032407 IBA MutSalpha complex binding
GO:0043060 IMP meiotic metaphase I plate congression
GO:0051026 IMP chiasma assembly

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000076242 MLH1 mutL homolog 1 protein_coding Homo_sapiens
ENSMUSG00000032498 Mlh1 mutL homolog 1 (E. coli) protein_coding Mus_musculus

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