C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mutL homolog 1 (E. coli)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000032498 Mlh1 10090 - 9:111228228-111271608 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000035079 Mlh1-001 111228254-111271608 protein_coding
  ENSMUST00000123713 Mlh1-007 111241279-111247745 retained_intron
  ENSMUST00000123869 Mlh1-003 111229888-111271600 retained_intron
  ENSMUST00000128795 Mlh1-004 111229870-111230948 retained_intron
  ENSMUST00000134316 Mlh1-005 111257157-111271534 processed_transcript
  ENSMUST00000135218 Mlh1-002 111228228-111271546 retained_intron
  ENSMUST00000135695 Mlh1-006 111249223-111261543 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000035079ENSMUST00000123713ENSMUST00000123869ENSMUST00000135218
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000035079 2.895±1.34 2.228±0.48 4.037±0.17 4.124±2.47 2.192±0.57 1.874±0.32 1.673±0.22 2.483±0.78 6.335±3.77 1.880±0.31 1.935±0.29 3.938±1.55 6.873±2.17 1.474±0.67
ENSMUST00000123713 3.043±0.00 4.968±1.26 N/A N/A 3.954±1.07 3.430±1.13 N/A N/A 1.675±0.00 2.112±0.70 N/A 5.574±1.77 N/A N/A
ENSMUST00000123869 N/A N/A N/A 0.743±0.00 N/A N/A N/A N/A N/A N/A 0.568±0.00 N/A N/A 0.419±0.00
ENSMUST00000135218 N/A 0.739±0.00 N/A N/A 0.578±0.13 0.544±0.21 0.237±0.00 0.334±0.00 0.663±0.10 0.553±0.03 0.217±0.00 0.727±0.13 N/A 0.157±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000289 IMP nuclear-transcribed mRNA poly(A) tail shortening
GO:0000712 IMP resolution of meiotic recombination intermediates
GO:0000793 IDA condensed chromosome
GO:0000794 IDA condensed nuclear chromosome
GO:0000795 IDA synaptonemal complex
GO:0001673 IDA male germ cell nucleus
GO:0002204 IGI somatic recombination of immunoglobulin genes involved in immune response
GO:0003697 IBA single-stranded DNA binding
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005694 IDA chromosome
GO:0005712 IDA chiasma
GO:0006200 IBA ATP catabolic process
GO:0006281 IMP DNA repair
GO:0006298 IMP mismatch repair
GO:0006303 IMP double-strand break repair via nonhomologous end joining
GO:0006974 IGI cellular response to DNA damage stimulus
GO:0007060 IMP male meiosis chromosome segregation
GO:0007126 TAS meiotic nuclear division
GO:0007129 IMP synapsis
GO:0007131 IMP reciprocal meiotic recombination
GO:0007140 IMP male meiosis
GO:0007283 IMP spermatogenesis
GO:0008630 IMP intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016020 IEA membrane
GO:0016446 IMP somatic hypermutation of immunoglobulin genes
GO:0016447 IMP somatic recombination of immunoglobulin gene segments
GO:0016887 IBA ATPase activity
GO:0032137 IGI guanine/thymine mispair binding
GO:0032389 IDA MutLalpha complex
GO:0032407 IEA MutSalpha complex binding
GO:0043060 IMP meiotic metaphase I plate congression
GO:0043566 IDA structure-specific DNA binding
GO:0045132 IMP meiotic chromosome segregation
GO:0045190 IMP isotype switching
GO:0045950 IMP negative regulation of mitotic recombination
GO:0048477 IMP oogenesis
GO:0051257 IMP spindle midzone assembly involved in meiosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000025948 mlh1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) protein_coding Danio_rerio
ENSG00000076242 MLH1 mutL homolog 1 protein_coding Homo_sapiens

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