C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nitric oxide synthase 2a, inducible
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSDARG00000026925 nos2a 7955 + 5:45400849-45415553 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSDART00000019431 nos2a-201 45402165-45415195 protein_coding
  ENSDART00000130355 nos2a-001 45400849-45415553 protein_coding
  ENSDART00000139182 nos2a-002 45401937-45403007 retained_intron
  ENSDART00000143982 nos2a-003 45403653-45404137 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainHeartKidneyMuscleENSDART00000019431ENSDART00000130355
Transcript ID Brain Heart Kidney Muscle
ENSDART00000019431 0.393±0.00 0.692±0.27 0.805±0.00 0.054±0.00
ENSDART00000130355 0.401±0.10 4.337±4.32 2.356±0.00 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003958 IBA NADPH-hemoprotein reductase activity
GO:0004517 IEA nitric-oxide synthase activity
GO:0005506 IEA iron ion binding
GO:0005516 IEA calmodulin binding
GO:0005829 IBA cytosol
GO:0006809 IEA nitric oxide biosynthetic process
GO:0006954 IBA inflammatory response
GO:0007263 IBA nitric oxide mediated signal transduction
GO:0009611 IDA response to wounding
GO:0010181 IEA FMN binding
GO:0016491 IEA oxidoreductase activity
GO:0020037 IEA heme binding
GO:0031284 IBA positive regulation of guanylate cyclase activity
GO:0032496 IDA response to lipopolysaccharide
GO:0042742 IBA defense response to bacterium
GO:0045776 IBA negative regulation of blood pressure
GO:0045909 IBA positive regulation of vasodilation
GO:0046872 IEA metal ion binding
GO:0050660 IEA flavin adenine dinucleotide binding
GO:0050661 IEA NADP binding
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000007171 NOS2 nitric oxide synthase 2, inducible protein_coding Homo_sapiens
ENSMUSG00000020826 Nos2 nitric oxide synthase 2, inducible protein_coding Mus_musculus

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