C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nitric oxide synthase 2, inducible
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000007171 NOS2 9606 - 17:27756766-27800499 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000313735 NOS2-001 27756766-27800499 protein_coding
  ENST00000621962 NOS2-201 27757246-27798809 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastHeartKidneyLungOvaryPlacentaENST00000313735ENST00000621962
Transcript ID Adrenal Brain Breast Heart Kidney Lung Ovary Placenta
ENST00000313735 2.815±0.00 0.905±0.22 0.480±0.00 0.013±0.00 0.737±0.00 4.445±0.00 N/A 0.881±0.00
ENST00000621962 N/A N/A 0.239±0.00 N/A N/A N/A 0.139±0.00 0.639±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007SM CIL_0007SM_0001 VISTA 17:27271510-27874835

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IEA response to hypoxia
GO:0001912 TAS positive regulation of leukocyte mediated cytotoxicity
GO:0002227 NAS innate immune response in mucosa
GO:0003958 IBA NADPH-hemoprotein reductase activity
GO:0004517 IDA:IEA nitric-oxide synthase activity
GO:0005102 IPI receptor binding
GO:0005506 IEA iron ion binding
GO:0005515 IPI protein binding
GO:0005516 IEA calmodulin binding
GO:0005622 IDA intracellular
GO:0005634 ISS nucleus
GO:0005737 IDA cytoplasm
GO:0005777 IDA peroxisome
GO:0005829 IMP cytosol
GO:0006527 IDA arginine catabolic process
GO:0006801 ISS superoxide metabolic process
GO:0006809 IDA:IEA nitric oxide biosynthetic process
GO:0006954 IBA inflammatory response
GO:0007263 IBA nitric oxide mediated signal transduction
GO:0007596 TAS blood coagulation
GO:0007623 IEA circadian rhythm
GO:0009617 NAS response to bacterium
GO:0010181 ISS:IEA FMN binding
GO:0010629 IGI negative regulation of gene expression
GO:0016491 IEA oxidoreductase activity
GO:0018119 ISS peptidyl-cysteine S-nitrosylation
GO:0020037 ISS:IEA heme binding
GO:0030863 IEA cortical cytoskeleton
GO:0031284 IBA positive regulation of guanylate cyclase activity
GO:0032496 IEA response to lipopolysaccharide
GO:0034617 ISS tetrahydrobiopterin binding
GO:0034618 ISS arginine binding
GO:0042127 IEA regulation of cell proliferation
GO:0042177 IEA negative regulation of protein catabolic process
GO:0042742 ISS defense response to bacterium
GO:0042803 ISS protein homodimerization activity
GO:0043457 TAS regulation of cellular respiration
GO:0045776 IBA negative regulation of blood pressure
GO:0045909 IBA positive regulation of vasodilation
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050660 ISS:IEA flavin adenine dinucleotide binding
GO:0050661 TAS:IEA NADP binding
GO:0050796 IMP regulation of insulin secretion
GO:0050829 NAS defense response to Gram-negative bacterium
GO:0051701 TAS interaction with host
GO:0051712 IMP positive regulation of killing of cells of other organism
GO:0055114 IEA oxidation-reduction process
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0071346 IEA cellular response to interferon-gamma
GO:0090382 TAS phagosome maturation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000026925 nos2a nitric oxide synthase 2a, inducible protein_coding Danio_rerio
ENSDARG00000031976 nos2b nitric oxide synthase 2b, inducible protein_coding Danio_rerio
ENSMUSG00000020826 Nos2 nitric oxide synthase 2, inducible protein_coding Mus_musculus

Loading