C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: maternal embryonic leucine zipper kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSDARG00000030759 melk 7955 - 1:20696018-20716785 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSDART00000047728 melk-201 20696354-20716785 protein_coding
  ENSDART00000125259 melk-202 20696018-20715668 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainHeartKidneyLiverMuscleENSDART00000047728ENSDART00000125259
Transcript ID Brain Heart Kidney Liver Muscle
ENSDART00000047728 0.178±0.10 0.254±0.00 5.227±0.00 N/A 0.078±0.00
ENSDART00000125259 0.192±0.17 0.814±0.25 1.934±0.59 0.054±0.00 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000166 IEA nucleotide binding
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004715 ISS non-membrane spanning protein tyrosine kinase activity
GO:0005509 ISS calcium ion binding
GO:0005524 IEA ATP binding
GO:0005886 IEA plasma membrane
GO:0005938 ISS cell cortex
GO:0006468 IEA protein phosphorylation
GO:0006915 ISS apoptotic process
GO:0007049 IEA cell cycle
GO:0008016 IMP regulation of heart contraction
GO:0008283 ISS cell proliferation
GO:0008289 IEA lipid binding
GO:0016020 IEA membrane
GO:0016301 IEA kinase activity
GO:0016310 IEA phosphorylation
GO:0016740 IEA transferase activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 ISS peptidyl-tyrosine phosphorylation
GO:0043065 ISS positive regulation of apoptotic process
GO:0046777 ISS protein autophosphorylation
GO:0048821 IMP erythrocyte development
GO:0061351 ISS neural precursor cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000165304 MELK maternal embryonic leucine zipper kinase protein_coding Homo_sapiens
ENSMUSG00000035683 Melk maternal embryonic leucine zipper kinase protein_coding Mus_musculus

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