C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: maternal embryonic leucine zipper kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000035683 Melk 10090 + 4:44300876-44364675 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000045607 Melk-001 44300876-44364675 protein_coding
  ENSMUST00000125708 Melk-003 44303568-44318070 protein_coding
  ENSMUST00000137703 Melk-002 44302667-44325693 protein_coding
  ENSMUST00000137759 Melk-004 44303568-44324268 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000045607ENSMUST00000125708ENSMUST00000137759
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000045607 1.077±0.94 0.282±0.06 0.302±0.04 2.592±2.33 0.547±0.20 2.728±0.30 0.060±0.00 0.144±0.06 5.065±5.13 0.444±0.19 0.021±0.01 1.569±1.05 7.674±4.99 1.033±0.19
ENSMUST00000125708 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.380±0.00 N/A
ENSMUST00000137759 N/A N/A N/A N/A 0.230±0.00 N/A 0.066±0.00 0.093±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006K5 CIL_0006K5_0002 CGP 4:44126210-44364675
CIL_0006K6 CIL_0006K6_0002 CGP 4:44300876-44710487

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IDA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004715 ISS non-membrane spanning protein tyrosine kinase activity
GO:0005509 ISS calcium ion binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0005886 ISS plasma membrane
GO:0005938 ISS cell cortex
GO:0006468 IEA protein phosphorylation
GO:0006915 ISS apoptotic process
GO:0007049 IEA cell cycle
GO:0008283 ISS cell proliferation
GO:0008289 IEA lipid binding
GO:0008631 IDA intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030097 ISS hemopoiesis
GO:0043065 IDA positive regulation of apoptotic process
GO:0046777 ISS protein autophosphorylation
GO:0061351 IDA neural precursor cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030759 melk maternal embryonic leucine zipper kinase protein_coding Danio_rerio
ENSG00000165304 MELK maternal embryonic leucine zipper kinase protein_coding Homo_sapiens

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