C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: maternal embryonic leucine zipper kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000165304 MELK 9606 + 9:36572862-36677683 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000298048 MELK-001 36572862-36677682 protein_coding
  ENST00000480021 MELK-004 36630007-36633200 processed_transcript
  ENST00000487398 MELK-002 36572924-36630367 processed_transcript
  ENST00000489766 MELK-003 36572897-36607622 processed_transcript
  ENST00000495529 MELK-005 36572897-36633155 processed_transcript
  ENST00000536329 MELK-201 36572862-36677683 protein_coding
  ENST00000536860 MELK-202 36572862-36677683 protein_coding
  ENST00000536987 MELK-203 36572862-36677683 protein_coding
  ENST00000541717 MELK-204 36572862-36677683 protein_coding
  ENST00000543751 MELK-205 36572862-36677683 protein_coding
  ENST00000545008 MELK-206 36572862-36677683 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000298048ENST00000480021ENST00000487398ENST00000489766ENST00000536329ENST00000536860ENST00000536987ENST00000541717ENST00000543751ENST00000545008
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000298048 N/A N/A N/A 0.282±0.00 N/A 0.123±0.00 0.116±0.00 N/A N/A 0.446±0.00 0.698±0.29 N/A
ENST00000480021 N/A N/A 0.134±0.00 N/A N/A N/A N/A 0.157±0.00 N/A N/A N/A N/A
ENST00000487398 N/A N/A N/A N/A 1.433±0.00 N/A N/A 0.075±0.00 0.073±0.00 N/A N/A N/A
ENST00000489766 N/A N/A N/A 1.139±0.00 N/A N/A N/A 0.539±0.00 N/A N/A N/A N/A
ENST00000536329 N/A N/A N/A 0.230±0.00 N/A N/A 0.022±0.00 N/A 0.125±0.00 N/A N/A N/A
ENST00000536860 N/A N/A N/A 0.896±0.00 N/A N/A N/A N/A N/A 0.732±0.00 N/A 1.811±0.00
ENST00000536987 N/A 0.122±0.00 N/A N/A N/A N/A 0.038±0.00 N/A N/A 0.525±0.00 0.537±0.05 N/A
ENST00000541717 N/A N/A N/A N/A 0.947±0.00 N/A N/A 0.088±0.00 N/A N/A 0.347±0.01 N/A
ENST00000543751 N/A N/A N/A 0.306±0.00 N/A N/A N/A N/A N/A 2.630±2.89 1.168±0.78 N/A
ENST00000545008 0.094±0.00 N/A N/A N/A N/A 0.145±0.00 N/A N/A N/A N/A 2.041±0.00 0.437±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006K5 CIL_0006K5_0001 CGP 9:36336396-36677683
CIL_0006K6 CIL_0006K6_0001 CGP 9:36572862-37034185

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000086 TAS G2/M transition of mitotic cell cycle
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004715 IDA non-membrane spanning protein tyrosine kinase activity
GO:0005509 IDA calcium ion binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005886 IDA plasma membrane
GO:0005938 IDA cell cortex
GO:0006468 IEA protein phosphorylation
GO:0006915 IDA apoptotic process
GO:0008283 IDA cell proliferation
GO:0008289 IEA lipid binding
GO:0008631 IEA intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0016020 IDA:IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030097 ISS hemopoiesis
GO:0043065 ISS positive regulation of apoptotic process
GO:0046777 IDA protein autophosphorylation
GO:0061351 ISS neural precursor cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030759 melk maternal embryonic leucine zipper kinase protein_coding Danio_rerio
ENSMUSG00000035683 Melk maternal embryonic leucine zipper kinase protein_coding Mus_musculus

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