C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: lymphocyte enhancer binding factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSDARG00000031894 lef1 7955 + 1:50321544-50410570 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSDART00000047876 lef1-002 50385083-50393595 protein_coding
  ENSDART00000132405 lef1-001 50321544-50410570 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainHeartKidneyLiverMuscleENSDART00000047876ENSDART00000132405
Transcript ID Brain Heart Kidney Liver Muscle
ENSDART00000047876 N/A 0.451±0.00 N/A N/A N/A
ENSDART00000132405 12.157±6.18 0.268±0.09 0.631±0.07 0.062±0.00 0.984±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000FF CIL_0000FF_0001 CGP 1:50321544-50426125

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001569 IBA patterning of blood vessels
GO:0001649 IBA osteoblast differentiation
GO:0001755 IMP neural crest cell migration
GO:0001756 IMP somitogenesis
GO:0001837 IBA epithelial to mesenchymal transition
GO:0002040 IBA sprouting angiogenesis
GO:0003677 ISS DNA binding
GO:0003682 IBA chromatin binding
GO:0003705 IBA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005667 IBA transcription factor complex
GO:0005737 IBA cytoplasm
GO:0006366 IBA transcription from RNA polymerase II promoter
GO:0008013 IBA beta-catenin binding
GO:0008301 ISS DNA binding, bending
GO:0010628 IMP positive regulation of gene expression
GO:0016055 IEA Wnt receptor signaling pathway
GO:0016202 IBA regulation of striated muscle tissue development
GO:0021542 IBA dentate gyrus development
GO:0021854 IMP hypothalamus development
GO:0021861 IBA forebrain radial glial cell differentiation
GO:0021873 IBA forebrain neuroblast division
GO:0021879 IMP forebrain neuron differentiation
GO:0021943 IBA formation of radial glial scaffolds
GO:0021979 IMP hypothalamus cell differentiation
GO:0022008 IGI neurogenesis
GO:0022407 IBA regulation of cell-cell adhesion
GO:0030223 IBA neutrophil differentiation
GO:0030326 IBA embryonic limb morphogenesis
GO:0030331 IBA estrogen receptor binding
GO:0030509 IBA BMP signaling pathway
GO:0030879 IBA mammary gland development
GO:0031101 IMP fin regeneration
GO:0032696 IBA negative regulation of interleukin-13 production
GO:0032713 IBA negative regulation of interleukin-4 production
GO:0032714 IBA negative regulation of interleukin-5 production
GO:0033333 IMP fin development
GO:0033334 IMP fin morphogenesis
GO:0033336 IMP caudal fin development
GO:0033339 IMP pectoral fin development
GO:0035326 IBA enhancer binding
GO:0042100 IBA B cell proliferation
GO:0043154 IBA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043565 IPI sequence-specific DNA binding
GO:0045295 IBA gamma-catenin binding
GO:0046632 IBA alpha-beta T cell differentiation
GO:0048069 IBA eye pigmentation
GO:0048341 IBA paraxial mesoderm formation
GO:0048747 IMP muscle fiber development
GO:0048916 IMP posterior lateral line development
GO:0048922 IMP posterior lateral line neuromast deposition
GO:0050769 IMP positive regulation of neurogenesis
GO:0060070 IMP canonical Wnt receptor signaling pathway
GO:0060325 IBA face morphogenesis
GO:0060561 IBA apoptotic process involved in morphogenesis
GO:0060784 IMP regulation of cell proliferation involved in tissue homeostasis
GO:0061153 IBA trachea gland development
GO:0070016 IBA armadillo repeat domain binding
GO:0071864 IBA positive regulation of cell proliferation in bone marrow
GO:0071866 IBA negative regulation of apoptotic process in bone marrow
GO:0071895 IBA odontoblast differentiation
GO:1900052 IGI regulation of retinoic acid biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000138795 LEF1 lymphoid enhancer-binding factor 1 protein_coding Homo_sapiens
ENSMUSG00000027985 Lef1 lymphoid enhancer binding factor 1 protein_coding Mus_musculus

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