C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: lymphoid enhancer binding factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027985 Lef1 10090 + 3:131110471-131224356 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000029611 Lef1-001 131110471-131224356 protein_coding
  ENSMUST00000066849 Lef1-006 131110471-131224356 protein_coding
  ENSMUST00000098611 Lef1-002 131112797-131224356 protein_coding
  ENSMUST00000106341 Lef1-004 131110471-131224356 protein_coding
  ENSMUST00000132737 Lef1-005 131112806-131188082 retained_intron
  ENSMUST00000136147 Lef1-003 131112797-131117387 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000029611ENSMUST00000066849ENSMUST00000098611ENSMUST00000106341ENSMUST00000132737
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000029611 1.475±1.66 N/A 0.938±0.18 N/A 4.277±2.46 0.545±0.17 0.059±0.02 0.395±0.25 0.206±0.27 1.090±0.37 0.141±0.09 0.433±0.20 0.169±0.10 N/A
ENSMUST00000066849 0.731±0.00 N/A N/A 4.187±0.36 N/A N/A N/A 0.072±0.00 0.052±0.00 N/A 0.098±0.00 0.202±0.04 0.059±0.04 N/A
ENSMUST00000098611 1.391±1.31 4.032±1.60 0.353±0.11 0.308±0.00 15.587±7.72 0.270±0.05 0.354±0.21 1.014±0.68 0.277±0.32 2.468±0.69 0.221±0.24 0.721±0.60 0.077±0.04 9.744±3.80
ENSMUST00000106341 N/A N/A N/A 5.716±0.67 N/A N/A N/A 0.117±0.00 0.038±0.00 N/A 0.042±0.01 0.281±0.12 0.018±0.00 3.072±0.06
ENSMUST00000132737 0.019±0.00 N/A N/A N/A N/A N/A N/A N/A 0.066±0.00 N/A N/A N/A 0.012±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008T5 CIL_0008T5_0002 VISTA 3:130661754-131264427
CIL_00097H CIL_00097H_0002 VISTA 3:130836337-131437858
CIL_0000FF CIL_0000FF_0002 CGP 3:131110471-131272101

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000977 IEA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001228 IEA RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001569 IMP patterning of blood vessels
GO:0001649 IBA osteoblast differentiation
GO:0001755 IBA neural crest cell migration
GO:0001756 IGI somitogenesis
GO:0001837 IMP epithelial to mesenchymal transition
GO:0001944 IMP vasculature development
GO:0002040 IMP sprouting angiogenesis
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IGI RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IPI transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0008013 IBA beta-catenin binding
GO:0008134 IPI transcription factor binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0008301 IDA DNA binding, bending
GO:0010628 IEA positive regulation of gene expression
GO:0010718 IEA positive regulation of epithelial to mesenchymal transition
GO:0016055 IGI Wnt signaling pathway
GO:0021542 IMP dentate gyrus development
GO:0021766 IMP hippocampus development
GO:0021854 IBA hypothalamus development
GO:0021861 IGI forebrain radial glial cell differentiation
GO:0021873 IGI forebrain neuroblast division
GO:0021879 IBA forebrain neuron differentiation
GO:0021943 IGI formation of radial glial scaffolds
GO:0022407 IMP regulation of cell-cell adhesion
GO:0022408 IEA negative regulation of cell-cell adhesion
GO:0022409 IEA positive regulation of cell-cell adhesion
GO:0030111 IGI regulation of Wnt signaling pathway
GO:0030223 IBA neutrophil differentiation
GO:0030284 IEA estrogen receptor activity
GO:0030307 IEA positive regulation of cell growth
GO:0030326 IGI embryonic limb morphogenesis
GO:0030331 IBA estrogen receptor binding
GO:0030335 IEA positive regulation of cell migration
GO:0030509 IDA BMP signaling pathway
GO:0030854 IEA positive regulation of granulocyte differentiation
GO:0030879 IMP mammary gland development
GO:0032696 IBA negative regulation of interleukin-13 production
GO:0032713 IBA negative regulation of interleukin-4 production
GO:0032714 IBA negative regulation of interleukin-5 production
GO:0032993 IEA protein-DNA complex
GO:0033153 IGI T cell receptor V(D)J recombination
GO:0035326 IBA enhancer binding
GO:0042100 IMP B cell proliferation
GO:0042393 IEA histone binding
GO:0042475 IMP odontogenesis of dentin-containing tooth
GO:0043027 IEA cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 IEA negative regulation of apoptotic process
GO:0043154 IBA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043392 IEA negative regulation of DNA binding
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IBA sequence-specific DNA binding
GO:0043586 IMP tongue development
GO:0043923 IEA positive regulation by host of viral transcription
GO:0043966 IEA histone H3 acetylation
GO:0043967 IEA histone H4 acetylation
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045063 IDA T-helper 1 cell differentiation
GO:0045295 IBA gamma-catenin binding
GO:0045843 IDA negative regulation of striated muscle tissue development
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046632 IGI alpha-beta T cell differentiation
GO:0048069 IBA eye pigmentation
GO:0048341 IGI paraxial mesoderm formation
GO:0048468 IGI cell development
GO:0048747 IBA muscle fiber development
GO:0050909 IMP sensory perception of taste
GO:0060021 IMP palate development
GO:0060033 IMP anatomical structure regression
GO:0060070 IBA canonical Wnt signaling pathway
GO:0060325 IGI face morphogenesis
GO:0060326 IEA cell chemotaxis
GO:0060561 IMP apoptotic process involved in morphogenesis
GO:0060710 IGI chorio-allantoic fusion
GO:0061153 IMP trachea gland development
GO:0070016 IBA armadillo repeat domain binding
GO:0070742 IEA C2H2 zinc finger domain binding
GO:0071345 IEA cellular response to cytokine stimulus
GO:0071353 IEA cellular response to interleukin-4
GO:0071864 IBA positive regulation of cell proliferation in bone marrow
GO:0071866 IBA negative regulation of apoptotic process in bone marrow
GO:0071895 IBA odontoblast differentiation
GO:0071899 IEA negative regulation of estrogen receptor binding
GO:0090068 IEA positive regulation of cell cycle process
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway
GO:1902262 IMP apoptotic process involved in patterning of blood vessels

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031894 lef1 lymphocyte enhancer binding factor 1 protein_coding Danio_rerio
ENSG00000138795 LEF1 lymphoid enhancer-binding factor 1 protein_coding Homo_sapiens

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