C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: lymphoid enhancer-binding factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000138795 LEF1 9606 - 4:108047545-108168956 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000265165 LEF1-001 108047545-108168422 protein_coding
  ENST00000379951 LEF1-201 108047545-108168956 protein_coding
  ENST00000438313 LEF1-020 108048417-108167798 protein_coding
  ENST00000503879 LEF1-017 108047573-108078352 processed_transcript
  ENST00000504426 LEF1-013 108047592-108071778 processed_transcript
  ENST00000504775 LEF1-008 108070662-108167594 processed_transcript
  ENST00000504950 LEF1-007 108078325-108166286 nonsense_mediated_decay
  ENST00000505293 LEF1-002 108083368-108166796 processed_transcript
  ENST00000505297 LEF1-011 108048354-108072896 processed_transcript
  ENST00000505328 LEF1-015 108070430-108078405 retained_intron
  ENST00000505379 LEF1-010 108048169-108083413 processed_transcript
  ENST00000506680 LEF1-019 108063629-108167767 nonsense_mediated_decay
  ENST00000507470 LEF1-016 108048527-108070895 retained_intron
  ENST00000509428 LEF1-009 108048597-108165195 processed_transcript
  ENST00000510135 LEF1-005 108048377-108165255 processed_transcript
  ENST00000510624 LEF1-018 108048639-108166721 protein_coding
  ENST00000510717 LEF1-004 108081621-108165257 processed_transcript
  ENST00000512172 LEF1-006 108083213-108166301 protein_coding
  ENST00000512407 LEF1-014 108048635-108072251 processed_transcript
  ENST00000514444 LEF1-012 108048300-108078382 processed_transcript
  ENST00000515500 LEF1-003 108081584-108166797 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000265165ENST00000379951ENST00000438313ENST00000503879ENST00000504426ENST00000504775ENST00000505293ENST00000505297ENST00000505379ENST00000507470ENST00000510135ENST00000514444ENST00000515500
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000265165 N/A N/A N/A N/A 2.000±0.00 N/A 0.025±0.00 0.246±0.00 0.384±0.00 N/A N/A 0.817±0.15 1.055±0.50 N/A
ENST00000379951 0.232±0.00 2.314±0.00 0.134±0.00 0.513±0.00 N/A 0.254±0.01 N/A 0.468±0.00 N/A 1.161±0.36 N/A 0.817±0.48 0.796±0.00 14.285±0.00
ENST00000438313 N/A N/A N/A 1.268±0.00 N/A 0.698±0.00 N/A N/A N/A 1.991±0.00 N/A 1.040±0.00 2.212±0.00 N/A
ENST00000503879 N/A N/A N/A N/A 2.193±0.00 0.548±0.00 N/A 0.995±0.00 N/A N/A N/A N/A N/A N/A
ENST00000504426 N/A 3.816±0.00 0.442±0.00 N/A N/A N/A 0.084±0.00 N/A 0.019±0.00 1.160±0.27 N/A N/A N/A N/A
ENST00000504775 N/A N/A N/A N/A N/A N/A 0.205±0.00 N/A N/A N/A N/A 1.512±0.00 N/A N/A
ENST00000505293 N/A N/A N/A 2.551±0.00 N/A N/A 0.143±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000505297 N/A N/A N/A N/A N/A 0.568±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000505379 N/A N/A N/A 0.952±0.00 N/A 0.396±0.00 N/A N/A 0.576±0.00 N/A N/A 2.271±0.00 1.373±0.00 N/A
ENST00000507470 N/A N/A N/A N/A N/A 0.924±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000510135 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.788±0.00 N/A
ENST00000514444 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.418±0.00 N/A N/A N/A
ENST00000515500 N/A N/A N/A N/A N/A N/A N/A N/A 0.977±0.00 N/A N/A 1.045±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00097H CIL_00097H_0001 VISTA 4:107841068-108442627
CIL_0008T5 CIL_0008T5_0001 VISTA 4:108033184-108635877

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000977 IDA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001228 IMP RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001569 IBA patterning of blood vessels
GO:0001649 IEP osteoblast differentiation
GO:0001755 IBA neural crest cell migration
GO:0001756 IBA somitogenesis
GO:0001837 ISS epithelial to mesenchymal transition
GO:0001944 IEA vasculature development
GO:0002040 IBA sprouting angiogenesis
GO:0003677 ISS DNA binding
GO:0003682 IBA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IBA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IDA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0008013 IPI beta-catenin binding
GO:0008134 IEA transcription factor binding
GO:0008284 IDA positive regulation of cell proliferation
GO:0008301 ISS DNA binding, bending
GO:0010628 IDA positive regulation of gene expression
GO:0010718 IMP positive regulation of epithelial to mesenchymal transition
GO:0016055 IDA Wnt signaling pathway
GO:0016202 IBA regulation of striated muscle tissue development
GO:0021542 IBA dentate gyrus development
GO:0021766 IEA hippocampus development
GO:0021854 IBA hypothalamus development
GO:0021861 IBA forebrain radial glial cell differentiation
GO:0021873 IBA forebrain neuroblast division
GO:0021879 IBA forebrain neuron differentiation
GO:0021943 IBA formation of radial glial scaffolds
GO:0022407 IEA regulation of cell-cell adhesion
GO:0022408 IDA negative regulation of cell-cell adhesion
GO:0022409 IDA positive regulation of cell-cell adhesion
GO:0030111 IEA regulation of Wnt signaling pathway
GO:0030223 IMP neutrophil differentiation
GO:0030284 IDA estrogen receptor activity
GO:0030307 IMP positive regulation of cell growth
GO:0030326 IBA embryonic limb morphogenesis
GO:0030331 IDA estrogen receptor binding
GO:0030335 IDA positive regulation of cell migration
GO:0030509 IBA BMP signaling pathway
GO:0030854 IDA positive regulation of granulocyte differentiation
GO:0030879 IBA mammary gland development
GO:0032696 IDA negative regulation of interleukin-13 production
GO:0032713 IDA negative regulation of interleukin-4 production
GO:0032714 IDA negative regulation of interleukin-5 production
GO:0032993 IDA protein-DNA complex
GO:0033153 IEA T cell receptor V(D)J recombination
GO:0035326 IDA enhancer binding
GO:0042100 IBA B cell proliferation
GO:0042393 IPI histone binding
GO:0042475 IEA odontogenesis of dentin-containing tooth
GO:0043027 IMP cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 IMP negative regulation of apoptotic process
GO:0043154 IMP negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043392 IDA negative regulation of DNA binding
GO:0043401 IDA steroid hormone mediated signaling pathway
GO:0043565 IDA sequence-specific DNA binding
GO:0043586 IEA tongue development
GO:0043923 IDA positive regulation by host of viral transcription
GO:0043966 IMP histone H3 acetylation
GO:0043967 IMP histone H4 acetylation
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045063 ISS T-helper 1 cell differentiation
GO:0045295 IPI gamma-catenin binding
GO:0045843 IEA negative regulation of striated muscle tissue development
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046632 IBA alpha-beta T cell differentiation
GO:0048069 IBA eye pigmentation
GO:0048341 IBA paraxial mesoderm formation
GO:0048468 IEA cell development
GO:0048747 IBA muscle fiber development
GO:0050909 IEA sensory perception of taste
GO:0060021 ISS palate development
GO:0060033 IEA anatomical structure regression
GO:0060070 IMP canonical Wnt signaling pathway
GO:0060325 IBA face morphogenesis
GO:0060326 IDA cell chemotaxis
GO:0060561 IBA apoptotic process involved in morphogenesis
GO:0060710 IBA chorio-allantoic fusion
GO:0061153 IBA trachea gland development
GO:0070016 IPI armadillo repeat domain binding
GO:0070742 IPI C2H2 zinc finger domain binding
GO:0071345 IMP cellular response to cytokine stimulus
GO:0071353 IDA cellular response to interleukin-4
GO:0071864 IMP positive regulation of cell proliferation in bone marrow
GO:0071866 IMP negative regulation of apoptotic process in bone marrow
GO:0071895 IBA odontoblast differentiation
GO:0071899 IDA negative regulation of estrogen receptor binding
GO:0090068 IDA positive regulation of cell cycle process
GO:0090090 IMP negative regulation of canonical Wnt signaling pathway
GO:1902262 IEA apoptotic process involved in patterning of blood vessels

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031894 lef1 lymphocyte enhancer binding factor 1 protein_coding Danio_rerio
ENSMUSG00000027985 Lef1 lymphoid enhancer binding factor 1 protein_coding Mus_musculus

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