C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transcription factor 7-like 1a (T-cell specific, HMG-box)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSDARG00000038159 tcf7l1a 7955 - 10:43560857-43663014 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSDART00000099262 tcf7l1a-201 43560860-43663014 protein_coding
  ENSDART00000138594 tcf7l1a-002 43564858-43567957 retained_intron
  ENSDART00000140341 tcf7l1a-001 43560857-43602429 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainHeartKidneyLiverMuscleENSDART00000099262ENSDART00000140341
Transcript ID Brain Heart Kidney Liver Muscle
ENSDART00000099262 1.277±0.58 5.358±1.34 3.786±0.00 0.386±0.00 2.266±0.00
ENSDART00000140341 0.228±0.00 11.584±2.06 4.746±1.53 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003677 IDA DNA binding
GO:0003682 IBA chromatin binding
GO:0003700 IBA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IBA transcription factor complex
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-dependent
GO:0006357 IBA regulation of transcription from RNA polymerase II promoter
GO:0007275 IEA multicellular organismal development
GO:0008013 IBA beta-catenin binding
GO:0008284 IGI positive regulation of cell proliferation
GO:0010456 IGI cell proliferation in dorsal spinal cord
GO:0016055 IEA Wnt receptor signaling pathway
GO:0021903 IMP rostrocaudal neural tube patterning
GO:0030178 IMP negative regulation of Wnt receptor signaling pathway
GO:0030900 IGI forebrain development
GO:0030901 IMP midbrain development
GO:0043565 IBA sequence-specific DNA binding
GO:0044212 IBA transcription regulatory region DNA binding
GO:0048596 IGI embryonic camera-type eye morphogenesis
GO:0048699 IGI generation of neurons
GO:0060070 IBA canonical Wnt receptor signaling pathway
GO:0060323 IMP head morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000152284 TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) protein_coding Homo_sapiens
ENSMUSG00000055799 Tcf7l1 transcription factor 7 like 1 (T cell specific, HMG box) protein_coding Mus_musculus

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