C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transcription factor 7-like 1 (T-cell specific, HMG-box)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000152284 TCF7L1 9606 + 2:85133410-85310388 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000282111 TCF7L1-001 85133410-85310388 protein_coding
  ENST00000442813 TCF7L1-004 85213623-85302494 protein_coding
  ENST00000490744 TCF7L1-003 85303393-85304364 retained_intron
  ENST00000494519 TCF7L1-002 85134368-85167373 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000282111ENST00000490744
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000282111 27.316±0.00 16.069±0.00 N/A 1.259±1.24 10.468±10.32 12.111±12.01 2.709±2.64 6.444±0.00 2.268±2.05 6.837±6.56 3.479±3.00 18.051±13.91 5.819±0.57 14.300±10.08
ENST00000490744 N/A N/A 1.027±0.00 0.057±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009AX CIL_0009AX_0001 VISTA 2:84977509-85579132

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003677 NAS DNA binding
GO:0003682 IBA chromatin binding
GO:0003700 NAS sequence-specific DNA binding transcription factor activity
GO:0005515 IEA protein binding
GO:0005634 NAS nucleus
GO:0005667 IBA transcription factor complex
GO:0006325 NAS chromatin organization
GO:0006351 IEA transcription, DNA-templated
GO:0006355 NAS regulation of transcription, DNA-templated
GO:0006357 IBA regulation of transcription from RNA polymerase II promoter
GO:0007420 IBA brain development
GO:0008013 IBA beta-catenin binding
GO:0008595 IEA anterior/posterior axis specification, embryo
GO:0030111 NAS regulation of Wnt signaling pathway
GO:0035019 IEA somatic stem cell maintenance
GO:0043565 IBA sequence-specific DNA binding
GO:0043588 IEA skin development
GO:0044212 IBA transcription regulatory region DNA binding
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0046022 IEA positive regulation of transcription from RNA polymerase II promoter during mitosis
GO:0048319 IEA axial mesoderm morphogenesis
GO:0048699 IBA generation of neurons
GO:0048863 IEA stem cell differentiation
GO:0060070 IBA canonical Wnt signaling pathway
GO:2000036 IEA regulation of stem cell maintenance

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007369 tcf7l1b transcription factor 7-like 1b (T-cell specific, HMG-box) protein_coding Danio_rerio
ENSDARG00000038159 tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) protein_coding Danio_rerio
ENSMUSG00000055799 Tcf7l1 transcription factor 7 like 1 (T cell specific, HMG box) protein_coding Mus_musculus

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