C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: chemokine (C-X-C motif), receptor 4b
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSDARG00000041959 cxcr4b 7955 + 9:10917685-10919710 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSDART00000061499 cxcr4b-001 10917685-10919710 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainHeartKidneyLiverMuscleENSDART00000061499
Transcript ID Brain Heart Kidney Liver Muscle
ENSDART00000061499 2.215±0.97 28.044±3.22 98.176±7.97 0.999±0.00 25.069±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001637 IMP G-protein coupled chemoattractant receptor activity
GO:0001667 IMP ameboidal cell migration
GO:0001764 IMP neuron migration
GO:0004871 IEA signal transducer activity
GO:0004930 IEA G-protein coupled receptor activity
GO:0004950 IEA chemokine receptor activity
GO:0005886 IDA plasma membrane
GO:0006935 IEA chemotaxis
GO:0007165 IEA signal transduction
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007281 IMP germ cell development
GO:0007411 IMP axon guidance
GO:0008354 IMP germ cell migration
GO:0009887 IMP organ morphogenesis
GO:0016020 IEA membrane
GO:0016021 IEA integral to membrane
GO:0016477 IMP cell migration
GO:0016494 IEA C-X-C chemokine receptor activity
GO:0030516 IMP regulation of axon extension
GO:0030900 IMP forebrain development
GO:0031290 IGI retinal ganglion cell axon guidance
GO:0032496 IMP response to lipopolysaccharide
GO:0042119 IEA neutrophil activation
GO:0042246 IEP tissue regeneration
GO:0048920 IGI posterior lateral line neuromast primordium migration
GO:0050918 IMP positive chemotaxis
GO:0050930 IMP induction of positive chemotaxis
GO:0090024 IMP negative regulation of neutrophil chemotaxis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000121966 CXCR4 chemokine (C-X-C motif) receptor 4 protein_coding Homo_sapiens
ENSMUSG00000045382 Cxcr4 chemokine (C-X-C motif) receptor 4 protein_coding Mus_musculus

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