C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: chemokine (C-X-C motif) receptor 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000045382 Cxcr4 10090 - 1:128588199-128592293 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000052172 Cxcr4-001 128588199-128592290 protein_coding
  ENSMUST00000142893 Cxcr4-002 128589099-128592293 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000052172ENSMUST00000142893
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000052172 6.818±0.92 6.703±3.48 1.894±0.29 8.261±5.96 12.043±3.09 3.188±0.73 3.266±0.52 2.085±0.49 4.167±4.85 33.793±5.45 1.114±0.59 4.079±0.92 1.065±0.57 1.256±0.53
ENSMUST00000142893 N/A N/A 1.184±0.00 7.834±0.00 N/A 1.938±0.03 N/A 1.345±0.00 2.048±1.95 31.258±0.00 0.555±0.10 3.818±0.59 1.286±0.51 1.617±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00077L CIL_00077L_0002 CGP 1:128363707-128592293
CIL_0006VZ CIL_0006VZ_0002 CGP 1:128588199-130219278

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001569 IMP patterning of blood vessels
GO:0001666 IEA response to hypoxia
GO:0001667 IMP ameboidal cell migration
GO:0001764 IDA neuron migration
GO:0003779 IEA actin binding
GO:0005515 IPI protein binding
GO:0005764 ISS lysosome
GO:0005769 ISS early endosome
GO:0005770 ISS late endosome
GO:0005886 ISS plasma membrane
GO:0005911 IDA cell-cell junction
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007281 IMP germ cell development
GO:0007399 TAS nervous system development
GO:0007420 IMP brain development
GO:0008045 IMP motor neuron axon guidance
GO:0008354 IMP germ cell migration
GO:0009887 TAS organ morphogenesis
GO:0009897 IDA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0016021 IEA integral component of membrane
GO:0016023 IEA cytoplasmic membrane-bounded vesicle
GO:0016494 IEA C-X-C chemokine receptor activity
GO:0019722 ISO calcium-mediated signaling
GO:0019955 IEA cytokine binding
GO:0030334 IMP regulation of cell migration
GO:0030426 IDA growth cone
GO:0031252 IEA cell leading edge
GO:0031410 IEA cytoplasmic vesicle
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032027 IEA myosin light chain binding
GO:0042098 IMP T cell proliferation
GO:0042119 IEA neutrophil activation
GO:0043130 IEA ubiquitin binding
GO:0043217 IMP myelin maintenance
GO:0048699 IEP generation of neurons
GO:0048714 IMP positive regulation of oligodendrocyte differentiation
GO:0050920 IEA regulation of chemotaxis
GO:0061351 IEP neural precursor cell proliferation
GO:0070062 IEA extracellular vesicular exosome
GO:0070098 IEA chemokine-mediated signaling pathway
GO:0071345 ISS cellular response to cytokine stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000041959 cxcr4b chemokine (C-X-C motif), receptor 4b protein_coding Danio_rerio
ENSDARG00000057633 cxcr4a chemokine (C-X-C motif) receptor 4a protein_coding Danio_rerio
ENSG00000121966 CXCR4 chemokine (C-X-C motif) receptor 4 protein_coding Homo_sapiens

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