C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: chemokine (C-X-C motif) receptor 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000121966 CXCR4 9606 - 2:136114349-136118165 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000241393 CXCR4-001 136114351-136118165 protein_coding
  ENST00000409817 CXCR4-003 136114349-136116243 protein_coding
  ENST00000466288 CXCR4-002 136114637-136117737 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000241393ENST00000409817
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000241393 30.603±0.00 179.648±0.00 N/A 1.327±0.05 6.537±0.08 5.842±2.40 1.539±0.73 3.437±1.76 6.253±2.18 39.318±19.95 1.629±0.35 15.105±8.51 23.372±3.01 7.606±1.05
ENST00000409817 N/A N/A 1.660±0.00 N/A 1.948±0.00 N/A N/A N/A N/A 4.484±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00077L CIL_00077L_0001 CGP 2:135906677-136118165
CIL_0006VZ CIL_0006VZ_0001 CGP 2:136114349-137677717

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 TAS activation of MAPK activity
GO:0001569 IEA patterning of blood vessels
GO:0001618 IEA virus receptor activity
GO:0001666 IEP response to hypoxia
GO:0001667 IEA ameboidal cell migration
GO:0001764 IEA neuron migration
GO:0002407 TAS dendritic cell chemotaxis
GO:0003779 IDA actin binding
GO:0004930 TAS:IEA G-protein coupled receptor activity
GO:0005515 IPI protein binding
GO:0005737 TAS cytoplasm
GO:0005764 IDA lysosome
GO:0005769 IDA early endosome
GO:0005770 IDA late endosome
GO:0005886 IDA plasma membrane
GO:0005911 IEA cell-cell junction
GO:0006915 TAS apoptotic process
GO:0006954 TAS inflammatory response
GO:0007186 IDA:IEA G-protein coupled receptor signaling pathway
GO:0007204 TAS positive regulation of cytosolic calcium ion concentration
GO:0007281 IEA germ cell development
GO:0007420 IEA brain development
GO:0008045 IEA motor neuron axon guidance
GO:0008354 IEA germ cell migration
GO:0009615 TAS response to virus
GO:0009897 IEA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0015026 TAS coreceptor activity
GO:0016021 IEA integral component of membrane
GO:0016023 IDA cytoplasmic membrane-bounded vesicle
GO:0016032 TAS viral process
GO:0016494 NAS C-X-C chemokine receptor activity
GO:0019722 IMP calcium-mediated signaling
GO:0019955 IEA cytokine binding
GO:0030260 TAS entry into host cell
GO:0030334 IEA regulation of cell migration
GO:0030426 IEA growth cone
GO:0031252 IDA cell leading edge
GO:0031410 IDA cytoplasmic vesicle
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032027 IDA myosin light chain binding
GO:0042098 IEA T cell proliferation
GO:0042119 IEA neutrophil activation
GO:0043130 IDA ubiquitin binding
GO:0043217 ISS myelin maintenance
GO:0048699 IEA generation of neurons
GO:0048714 ISS positive regulation of oligodendrocyte differentiation
GO:0050920 IMP regulation of chemotaxis
GO:0061351 IEA neural precursor cell proliferation
GO:0070062 IDA extracellular vesicular exosome
GO:0070098 IEA chemokine-mediated signaling pathway
GO:0071345 IDA cellular response to cytokine stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000041959 cxcr4b chemokine (C-X-C motif), receptor 4b protein_coding Danio_rerio
ENSDARG00000057633 cxcr4a chemokine (C-X-C motif) receptor 4a protein_coding Danio_rerio
ENSMUSG00000045382 Cxcr4 chemokine (C-X-C motif) receptor 4 protein_coding Mus_musculus

Loading