C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSDARG00000090044 mthfd2 7955 + 5:72657744-72762606 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSDART00000043920 mthfd2-201 72657744-72762596 protein_coding
  ENSDART00000125952 mthfd2-001 72746310-72762606 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainHeartKidneyLiverMuscleENSDART00000043920ENSDART00000125952
Transcript ID Brain Heart Kidney Liver Muscle
ENSDART00000043920 1.591±1.00 1.905±0.87 N/A N/A 0.828±0.00
ENSDART00000125952 1.218±0.40 1.955±0.23 0.882±0.00 0.083±0.00 0.398±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002DN CIL_0002DN_0001 CGP 5:72649226-72762606

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003824 IEA catalytic activity
GO:0004477 IBA methenyltetrahydrofolate cyclohydrolase activity
GO:0004487 IBA methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488 IEA methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005739 IBA mitochondrion
GO:0006730 IBA one-carbon metabolic process
GO:0009396 IEA folic acid-containing compound biosynthetic process
GO:0016787 IEA hydrolase activity
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000065911 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase protein_coding Homo_sapiens
ENSMUSG00000005667 Mthfd2 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase protein_coding Mus_musculus

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