C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000005667 Mthfd2 10090 - 6:83305691-83317606 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000005810 Mthfd2-001 83305691-83317606 protein_coding
  ENSMUST00000139802 Mthfd2-003 83309334-83310548 processed_transcript
  ENSMUST00000141044 Mthfd2-004 83306558-83309307 processed_transcript
  ENSMUST00000141193 Mthfd2-002 83309552-83311593 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000005810ENSMUST00000139802ENSMUST00000141044
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000005810 2.634±0.98 3.082±0.74 1.784±0.41 4.642±2.71 2.803±1.17 2.275±0.53 0.625±0.14 1.295±0.11 14.553±16.37 1.188±0.27 1.634±0.29 4.742±1.78 7.948±3.80 7.434±2.42
ENSMUST00000139802 N/A N/A N/A 4.362±0.00 N/A N/A N/A N/A N/A N/A N/A 13.917±0.00 38.477±0.00 8.809±0.00
ENSMUST00000141044 N/A N/A N/A N/A N/A N/A N/A N/A 0.189±0.01 N/A N/A N/A N/A 3.028±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0004477 IBA methenyltetrahydrofolate cyclohydrolase activity
GO:0004487 IBA methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488 IBA methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005615 IEA extracellular space
GO:0005739 IDA mitochondrion
GO:0006730 IBA one-carbon metabolic process
GO:0009396 IEA folic acid-containing compound biosynthetic process
GO:0042301 IEA phosphate ion binding
GO:0046653 IEA tetrahydrofolate metabolic process
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000090044 mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase protein_coding Danio_rerio
ENSG00000065911 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase protein_coding Homo_sapiens

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