C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: FGR proto-oncogene, Src family tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000000938 FGR 9606 - 1:27612064-27635277 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000374003 FGR-002 27612669-27626569 protein_coding
  ENST00000374004 FGR-004 27612300-27624062 protein_coding
  ENST00000374005 FGR-001 27612064-27635277 protein_coding
  ENST00000399173 FGR-201 27612292-27626240 protein_coding
  ENST00000457296 FGR-007 27615514-27626135 protein_coding
  ENST00000468038 FGR-006 27623407-27626240 processed_transcript
  ENST00000475472 FGR-005 27623384-27635134 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000374003ENST00000374004ENST00000374005ENST00000399173ENST00000457296ENST00000475472
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000374003 N/A 4.066±0.00 0.222±0.00 1.138±0.86 N/A 0.400±0.00 N/A 0.706±0.00 7.901±0.00 0.566±0.00 0.164±0.00 N/A 0.352±0.00
ENST00000374004 3.986±0.00 1.390±0.00 0.964±0.00 1.927±0.00 1.116±0.69 2.474±0.00 2.963±1.12 2.429±0.00 9.827±0.00 0.710±0.00 1.876±0.53 2.361±0.27 0.575±0.21
ENST00000374005 N/A 1.093±0.00 N/A 0.104±0.00 N/A N/A 0.564±0.00 N/A N/A N/A 0.439±0.00 N/A N/A
ENST00000399173 1.986±0.00 1.367±0.00 N/A 0.912±0.00 N/A N/A N/A N/A 6.831±0.00 N/A N/A 2.889±0.78 N/A
ENST00000457296 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.402±0.00 N/A N/A 0.344±0.00
ENST00000475472 N/A N/A 0.121±0.00 N/A N/A N/A 0.878±0.00 0.857±0.00 N/A 1.357±0.00 N/A N/A 0.356±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008WN CIL_0008WN_0001 VISTA 1:27203963-27805666

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001784 ISS phosphotyrosine binding
GO:0002768 TAS immune response-regulating cell surface receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0004715 IDA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005743 IEA mitochondrial inner membrane
GO:0005829 TAS cytosol
GO:0005856 IDA cytoskeleton
GO:0005886 ISS plasma membrane
GO:0006468 TAS:IEA protein phosphorylation
GO:0007229 ISS integrin-mediated signaling pathway
GO:0007596 TAS blood coagulation
GO:0008360 ISS regulation of cell shape
GO:0009615 TAS response to virus
GO:0014068 IMP positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015629 ISS actin cytoskeleton
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019901 ISS protein kinase binding
GO:0030335 ISS positive regulation of cell migration
GO:0032587 ISS ruffle membrane
GO:0034987 ISS immunoglobulin receptor binding
GO:0034988 IDA Fc-gamma receptor I complex binding
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043306 ISS positive regulation of mast cell degranulation
GO:0043552 IMP positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 IEA:TAS innate immune response
GO:0045088 ISS regulation of innate immune response
GO:0045859 ISS regulation of protein kinase activity
GO:0046777 IDA protein autophosphorylation
GO:0050715 ISS positive regulation of cytokine secretion
GO:0050764 ISS regulation of phagocytosis
GO:0050830 ISS defense response to Gram-positive bacterium
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000028874 Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog protein_coding Mus_musculus

Loading