C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: FGR proto-oncogene, Src family tyrosine kinase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000374004 FGR-004 ENSG00000000938 9606 - 1:27612300-27624062 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000374004
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000374004 3.986±0.00 1.390±0.00 0.964±0.00 1.927±0.00 1.116±0.69 2.474±0.00 2.963±1.12 2.429±0.00 9.827±0.00 0.710±0.00 1.876±0.53 2.361±0.27 0.575±0.21

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008WN CIL_0008WN_0001 VISTA 1:27203963-27805666

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001784 ISS phosphotyrosine binding
GO:0002768 TAS immune response-regulating cell surface receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0004715 IDA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005743 IEA mitochondrial inner membrane
GO:0005829 TAS cytosol
GO:0005856 IDA cytoskeleton
GO:0005886 ISS plasma membrane
GO:0006468 TAS:IEA protein phosphorylation
GO:0007229 ISS integrin-mediated signaling pathway
GO:0007596 TAS blood coagulation
GO:0008360 ISS regulation of cell shape
GO:0009615 TAS response to virus
GO:0014068 IMP positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015629 ISS actin cytoskeleton
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019901 ISS protein kinase binding
GO:0030335 ISS positive regulation of cell migration
GO:0032587 ISS ruffle membrane
GO:0034987 ISS immunoglobulin receptor binding
GO:0034988 IDA Fc-gamma receptor I complex binding
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043306 ISS positive regulation of mast cell degranulation
GO:0043552 IMP positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 IEA:TAS innate immune response
GO:0045088 ISS regulation of innate immune response
GO:0045859 ISS regulation of protein kinase activity
GO:0046777 IDA protein autophosphorylation
GO:0050715 ISS positive regulation of cytokine secretion
GO:0050764 ISS regulation of phagocytosis
GO:0050830 ISS defense response to Gram-positive bacterium
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000171223 Fgr-201 protein_coding Mus_musculus 0 1483
ENSMUST00000138179 Fgr-002 processed_transcript Mus_musculus 0 1483
ENSMUST00000030693 Fgr-001 protein_coding Mus_musculus 0 1483
ENSMUST00000167288 Lck-201 protein_coding Mus_musculus 0 252
ENSMUST00000102596 Lck-001 protein_coding Mus_musculus 0 252
ENSMUST00000067240 Lck-002 protein_coding Mus_musculus 0 252
ENSMUST00000132030 Lck-007 retained_intron Mus_musculus 0 241
ENSDART00000020099 blk-201 protein_coding Danio_rerio 0.000000002 69
ENSDART00000138028 blk-001 protein_coding Danio_rerio 0.000000002 69

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