C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000028874 Fgr 10090 + 4:132974095-133001910 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000030693 Fgr-001 132974102-133001910 protein_coding
  ENSMUST00000124451 Fgr-003 132974095-132984360 processed_transcript
  ENSMUST00000138179 Fgr-002 132977116-133000767 processed_transcript
  ENSMUST00000171223 Fgr-201 132977116-133000767 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000030693ENSMUST00000124451ENSMUST00000171223
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000030693 0.815±0.38 0.133±0.04 0.371±0.01 0.021±0.01 2.334±0.63 0.670±0.11 0.199±0.09 0.432±0.14 0.750±0.60 3.620±0.59 0.191±0.22 0.368±0.24 0.143±0.06 0.101±0.06
ENSMUST00000124451 N/A 0.457±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.097±0.00 N/A N/A N/A
ENSMUST00000171223 1.171±0.49 0.296±0.17 0.375±0.05 0.066±0.06 3.506±0.80 0.908±0.26 0.342±0.19 0.518±0.12 0.337±0.14 5.839±0.64 0.043±0.01 0.881±0.40 0.272±0.11 0.407±0.18

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008WN CIL_0008WN_0002 VISTA 4:132816592-133418424

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001784 IDA phosphotyrosine binding
GO:0004715 IDA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005743 IEA mitochondrial inner membrane
GO:0005829 IEA cytosol
GO:0005856 IEA cytoskeleton
GO:0005886 IDA plasma membrane
GO:0007229 IMP integrin-mediated signaling pathway
GO:0008360 IMP regulation of cell shape
GO:0014068 IEA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015629 IDA actin cytoskeleton
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019901 IDA protein kinase binding
GO:0030335 IMP positive regulation of cell migration
GO:0032587 IDA ruffle membrane
GO:0032956 TAS regulation of actin cytoskeleton organization
GO:0034987 IDA immunoglobulin receptor binding
GO:0034988 IEA Fc-gamma receptor I complex binding
GO:0043306 IDA positive regulation of mast cell degranulation
GO:0043552 IEA positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 IEA innate immune response
GO:0045088 IMP regulation of innate immune response
GO:0045859 IDA regulation of protein kinase activity
GO:0046777 IEA protein autophosphorylation
GO:0050715 IDA positive regulation of cytokine secretion
GO:0050764 IMP regulation of phagocytosis
GO:0050830 IGI defense response to Gram-positive bacterium
GO:0070062 IEA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000000938 FGR FGR proto-oncogene, Src family tyrosine kinase protein_coding Homo_sapiens

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