C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: BCL2-associated agonist of cell death
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000002330 BAD 9606 - 11:64269830-64284704 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000309032 BAD-001 64269834-64284669 protein_coding
  ENST00000394531 BAD-003 64270256-64284653 protein_coding
  ENST00000394532 BAD-002 64269830-64284639 protein_coding
  ENST00000492141 BAD-005 64270308-64272856 protein_coding
  ENST00000493798 BAD-004 64270269-64271868 protein_coding
  ENST00000544271 BAD-007 64276761-64284704 retained_intron
  ENST00000544785 BAD-008 64270001-64284369 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000309032ENST00000394531ENST00000394532ENST00000493798ENST00000544271ENST00000544785
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000309032 23.570±0.00 27.438±0.00 N/A 12.665±8.88 17.232±15.84 17.654±15.26 13.783±12.20 33.174±0.00 9.006±7.45 18.263±17.23 10.384±0.00 18.328±17.22 74.227±36.93 51.784±0.00
ENST00000394531 N/A N/A N/A 5.485±0.00 0.872±0.00 N/A N/A 2.206±0.00 N/A N/A N/A N/A N/A N/A
ENST00000394532 N/A N/A N/A N/A N/A N/A N/A 2.675±0.00 N/A N/A N/A N/A N/A N/A
ENST00000493798 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 8.841±0.00 51.987±0.00 N/A
ENST00000544271 N/A N/A 2.223±0.00 N/A N/A N/A N/A N/A N/A 1.614±0.00 N/A N/A N/A N/A
ENST00000544785 N/A N/A N/A N/A N/A N/A N/A N/A 1.086±0.00 1.191±0.00 2.133±0.00 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IEA response to hypoxia
GO:0001836 IEA release of cytochrome c from mitochondria
GO:0005515 IPI protein binding
GO:0005543 IMP phospholipid binding
GO:0005737 IEA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005741 IDA mitochondrial outer membrane
GO:0005829 IDA cytosol
GO:0006007 IEA glucose catabolic process
GO:0006915 IDA apoptotic process
GO:0006919 ISS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0008283 IEA cell proliferation
GO:0008289 IDA lipid binding
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0008625 IEA extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 IEA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008656 IDA cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0009725 IEA response to hormone
GO:0009749 IEA response to glucose
GO:0010033 IEA response to organic substance
GO:0010508 TAS positive regulation of autophagy
GO:0010918 ISS positive regulation of mitochondrial membrane potential
GO:0014070 IEA response to organic cyclic compound
GO:0019050 IEA suppression by virus of host apoptotic process
GO:0019221 IEA cytokine-mediated signaling pathway
GO:0019901 IPI protein kinase binding
GO:0019903 IEA protein phosphatase binding
GO:0030346 IEA protein phosphatase 2B binding
GO:0032024 ISS positive regulation of insulin secretion
GO:0032355 IEA response to estradiol
GO:0032570 IEA response to progesterone
GO:0033133 ISS positive regulation of glucokinase activity
GO:0033574 IEA response to testosterone
GO:0034201 IEA response to oleic acid
GO:0035774 IEA positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042493 IEA response to drug
GO:0042542 IEA response to hydrogen peroxide
GO:0042593 ISS glucose homeostasis
GO:0042981 IEA regulation of apoptotic process
GO:0043065 IMP positive regulation of apoptotic process
GO:0043200 IEA response to amino acid
GO:0043280 IDA positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 IEA regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043422 IEA protein kinase B binding
GO:0044342 ISS type B pancreatic cell proliferation
GO:0045087 TAS innate immune response
GO:0045471 IEA response to ethanol
GO:0045579 IEA positive regulation of B cell differentiation
GO:0045582 IEA positive regulation of T cell differentiation
GO:0045862 IDA positive regulation of proteolysis
GO:0046031 ISS ADP metabolic process
GO:0046034 ISS ATP metabolic process
GO:0046902 IMP regulation of mitochondrial membrane permeability
GO:0046931 IDA pore complex assembly
GO:0046982 IEA protein heterodimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0050679 IMP positive regulation of epithelial cell proliferation
GO:0051384 IEA response to glucocorticoid
GO:0051592 IEA response to calcium ion
GO:0060139 IEA positive regulation of apoptotic process by virus
GO:0060154 IEA cellular process regulating host cell cycle in response to virus
GO:0071247 IEA cellular response to chromate
GO:0071260 IEP cellular response to mechanical stimulus
GO:0071316 IDA cellular response to nicotine
GO:0071396 IEA cellular response to lipid
GO:0071456 IEP cellular response to hypoxia
GO:0090200 IMP positive regulation of release of cytochrome c from mitochondria
GO:0097190 TAS apoptotic signaling pathway
GO:0097191 IMP extrinsic apoptotic signaling pathway
GO:0097192 IEA extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193 IMP intrinsic apoptotic signaling pathway
GO:0097202 IDA activation of cysteine-type endopeptidase activity
GO:1900740 TAS positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901216 IEA positive regulation of neuron death
GO:2000078 ISS positive regulation of type B pancreatic cell development
GO:2001244 TAS positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000054937 badb BCL2-antagonist of cell death b protein_coding Danio_rerio
ENSDARG00000087993 bada BCL2-antagonist of cell death a protein_coding Danio_rerio
ENSMUSG00000024959 Bad BCL2-associated agonist of cell death protein_coding Mus_musculus

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