C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: signal peptide peptidase like 2B
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000005206 SPPL2B 9606 + 19:2328615-2354806 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000585725 SPPL2B-009 2328615-2338526 processed_transcript
  ENST00000586111 SPPL2B-015 2330297-2330759 processed_transcript
  ENST00000586332 SPPL2B-008 2328659-2337482 nonsense_mediated_decay
  ENST00000587851 SPPL2B-011 2334629-2337935 retained_intron
  ENST00000589515 SPPL2B-012 2342722-2353567 retained_intron
  ENST00000593243 SPPL2B-010 2337111-2339877 processed_transcript
  ENST00000610743 SPPL2B-013 2328693-2353933 protein_coding
  ENST00000612623 SPPL2B-014 2339158-2343972 protein_coding
  ENST00000613503 SPPL2B-002 2328630-2354806 protein_coding
  ENST00000614784 SPPL2B-006 2339678-2341956 retained_intron
  ENST00000614794 SPPL2B-004 2328684-2341468 protein_coding
  ENST00000618220 SPPL2B-005 2328696-2342503 protein_coding
  ENST00000621568 SPPL2B-001 2328673-2343292 nonsense_mediated_decay
  ENST00000622308 SPPL2B-007 2338760-2341187 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderTestisENST00000610743ENST00000613503
Transcript ID Bladder Testis
ENST00000610743 N/A 34.621±2.16
ENST00000613503 1.339±0.00 22.694±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001SY CIL_0001SY_0001 CGP 19:2289784-2328620
CIL_0001IB CIL_0001IB_0001 CGP 19:2321517-2354806
CIL_0003DX CIL_0003DX_0001 CGP 19:2328615-2426239

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004190 IEA aspartic-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005765 IDA lysosomal membrane
GO:0005886 IDA plasma membrane
GO:0006509 IDA membrane protein ectodomain proteolysis
GO:0010008 IDA endosome membrane
GO:0016021 IEA integral component of membrane
GO:0030660 IDA Golgi-associated vesicle membrane
GO:0031293 IDA membrane protein intracellular domain proteolysis
GO:0042500 IMP aspartic endopeptidase activity, intramembrane cleaving
GO:0042803 IDA protein homodimerization activity
GO:0050776 IMP regulation of immune response
GO:0071458 IDA integral component of cytoplasmic side of endoplasmic reticulum membrane
GO:0071556 IDA integral component of lumenal side of endoplasmic reticulum membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030448 sppl2 signal peptide peptidase-like 2 protein_coding Danio_rerio
ENSMUSG00000035206 Sppl2b signal peptide peptidase like 2B protein_coding Mus_musculus

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