C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: arachidonate 5-lipoxygenase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000012779 ALOX5 9606 + 10:45374176-45446119 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000374391 ALOX5-001 45374227-45446115 protein_coding
  ENST00000475300 ALOX5-004 45440430-45441585 processed_transcript
  ENST00000481117 ALOX5-006 45443242-45444232 processed_transcript
  ENST00000483623 ALOX5-003 45424084-45428486 processed_transcript
  ENST00000493336 ALOX5-005 45442613-45443447 processed_transcript
  ENST00000498461 ALOX5-002 45443421-45444214 processed_transcript
  ENST00000542434 ALOX5-201 45374176-45446119 protein_coding
  ENST00000612635 ALOX5-202 45374280-45445687 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000374391ENST00000481117ENST00000483623ENST00000493336ENST00000542434ENST00000612635
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000374391 3.705±0.00 14.485±0.00 N/A 0.958±0.69 1.725±0.36 0.933±0.20 2.118±0.00 3.427±0.00 1.670±0.63 8.433±0.71 0.035±0.00 2.454±1.17 9.778±1.08 1.092±0.55
ENST00000481117 N/A N/A N/A N/A 4.664±0.00 N/A N/A N/A N/A N/A 0.429±0.00 N/A N/A N/A
ENST00000483623 N/A N/A N/A N/A N/A 4.375±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000493336 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.319±0.00 N/A N/A N/A
ENST00000542434 0.770±0.00 6.205±0.00 0.345±0.00 N/A N/A N/A N/A N/A 0.669±0.00 N/A N/A 0.421±0.00 N/A 0.740±0.36
ENST00000612635 N/A N/A N/A N/A N/A N/A N/A 3.402±0.00 N/A 9.514±0.00 N/A N/A N/A 0.320±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00081B CIL_00081B_0001 VISTA 10:45257434-45860222

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002540 IEA leukotriene production involved in inflammatory response
GO:0004051 IDA arachidonate 5-lipoxygenase activity
GO:0005506 IDA iron ion binding
GO:0005515 IPI:IEA protein binding
GO:0005615 IDA extracellular space
GO:0005634 IEA nucleus
GO:0005635 IDA nuclear envelope
GO:0005641 IDA nuclear envelope lumen
GO:0005737 IEA cytoplasm
GO:0005829 IDA cytosol
GO:0006691 TAS leukotriene metabolic process
GO:0006954 IEA inflammatory response
GO:0016363 IDA nuclear matrix
GO:0016702 IEA oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0019369 TAS arachidonic acid metabolic process
GO:0019370 IDA leukotriene biosynthetic process
GO:0019372 TAS lipoxygenase pathway
GO:0031965 IDA nuclear membrane
GO:0044281 TAS small molecule metabolic process
GO:0046872 IEA metal ion binding
GO:0055114 IEA oxidation-reduction process
GO:2001300 TAS lipoxin metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000043085 ALOX5 (1 of 4) arachidonate 5-lipoxygenase protein_coding Danio_rerio
ENSDARG00000043089 alox5b.2 arachidonate 5-lipoxygenase b, tandem duplicate 2 protein_coding Danio_rerio
ENSDARG00000057273 alox5a arachidonate 5-lipoxygenase a protein_coding Danio_rerio
ENSDARG00000069966 alox5b.3 arachidonate 5-lipoxygenase b, tandem duplicate 3 protein_coding Danio_rerio
ENSMUSG00000025701 Alox5 arachidonate 5-lipoxygenase protein_coding Mus_musculus

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