C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: arachidonate 5-lipoxygenase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000025701 Alox5 10090 - 6:116410077-116461178 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000026795 Alox5-001 116410077-116461178 protein_coding
  ENSMUST00000164547 Alox5-004 116410719-116461024 protein_coding
  ENSMUST00000167174 Alox5-006 116415470-116424963 processed_transcript
  ENSMUST00000167447 Alox5-002 116410274-116461131 retained_intron
  ENSMUST00000167585 Alox5-007 116412591-116414020 retained_intron
  ENSMUST00000169625 Alox5-003 116410276-116412792 retained_intron
  ENSMUST00000170186 Alox5-005 116410719-116461024 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000026795ENSMUST00000164547ENSMUST00000167174ENSMUST00000167447ENSMUST00000167585ENSMUST00000169625ENSMUST00000170186
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000026795 1.746±0.17 0.982±0.19 1.107±0.02 N/A 2.032±0.35 1.770±0.29 2.936±0.25 0.181±0.05 1.448±0.80 3.638±0.41 0.102±0.07 0.353±0.13 0.212±0.11 N/A
ENSMUST00000164547 N/A N/A N/A 0.290±0.00 2.088±0.00 N/A N/A 0.105±0.00 0.022±0.00 N/A 0.142±0.01 0.224±0.05 0.133±0.09 N/A
ENSMUST00000167174 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.194±0.03 N/A N/A N/A
ENSMUST00000167447 0.173±0.00 N/A 0.192±0.04 0.090±0.03 0.310±0.05 0.341±0.06 N/A 0.045±0.02 0.098±0.07 0.538±0.09 0.049±0.02 0.133±0.04 N/A N/A
ENSMUST00000167585 N/A N/A N/A 0.435±0.26 N/A N/A N/A 0.540±0.00 N/A N/A N/A 0.734±0.06 0.720±0.43 N/A
ENSMUST00000169625 0.703±0.00 N/A 0.556±0.00 0.224±0.00 N/A N/A N/A 0.208±0.06 0.169±0.15 N/A 0.217±0.07 0.414±0.11 0.331±0.07 1.008±0.45
ENSMUST00000170186 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.077±0.00 0.308±0.09 0.322±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00081B CIL_00081B_0002 VISTA 6:116052182-116663911

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002540 IMP leukotriene production involved in inflammatory response
GO:0004051 IEA arachidonate 5-lipoxygenase activity
GO:0005506 ISS iron ion binding
GO:0005515 IPI protein binding
GO:0005615 IEA extracellular space
GO:0005634 IDA nucleus
GO:0005635 IEA nuclear envelope
GO:0005641 ISS nuclear envelope lumen
GO:0005737 IDA cytoplasm
GO:0005829 ISS cytosol
GO:0006691 IMP leukotriene metabolic process
GO:0006954 IMP inflammatory response
GO:0016363 IEA nuclear matrix
GO:0016702 IEA oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0019370 IDA leukotriene biosynthetic process
GO:0031965 ISS nuclear membrane
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000043085 ALOX5 (1 of 4) arachidonate 5-lipoxygenase protein_coding Danio_rerio
ENSDARG00000043089 alox5b.2 arachidonate 5-lipoxygenase b, tandem duplicate 2 protein_coding Danio_rerio
ENSDARG00000057273 alox5a arachidonate 5-lipoxygenase a protein_coding Danio_rerio
ENSDARG00000069966 alox5b.3 arachidonate 5-lipoxygenase b, tandem duplicate 3 protein_coding Danio_rerio
ENSG00000012779 ALOX5 arachidonate 5-lipoxygenase protein_coding Homo_sapiens

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