C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ATPase, Na+/K+ transporting, alpha 2 polypeptide
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000018625 ATP1A2 9606 + 1:160115759-160143591 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000361216 ATP1A2-001 160115773-160143591 protein_coding
  ENST00000392233 ATP1A2-003 160115777-160141545 protein_coding
  ENST00000447527 ATP1A2-008 160127672-160143591 protein_coding
  ENST00000459972 ATP1A2-004 160139959-160141777 processed_transcript
  ENST00000463989 ATP1A2-005 160136671-160140058 retained_intron
  ENST00000468587 ATP1A2-006 160123958-160125542 retained_intron
  ENST00000472488 ATP1A2-002 160115759-160137202 retained_intron
  ENST00000478587 ATP1A2-007 160115763-160121275 retained_intron

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000361216ENST00000447527ENST00000459972ENST00000463989
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000361216 7.956±0.00 3.337±0.00 103.195±55.19 6.109±4.01 10.693±8.03 29.357±23.30 0.853±0.82 5.048±0.00 N/A 89.664±0.00 2.121±1.67 1.448±0.84 7.472±6.43
ENST00000447527 1.488±0.00 N/A 58.321±44.45 6.333±0.00 17.122±0.00 13.626±0.00 0.916±0.00 0.997±0.84 0.690±0.00 95.756±0.00 0.580±0.38 0.894±0.46 4.560±2.32
ENST00000459972 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.932±0.00 N/A N/A
ENST00000463989 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.141±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005I6 CIL_0005I6_0001 CGP 1:160091340-160143591

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000166 IEA nucleotide binding
GO:0001504 IEA neurotransmitter uptake
GO:0002026 IEA regulation of the force of heart contraction
GO:0002087 IEA regulation of respiratory gaseous exchange by neurological system process
GO:0005391 IDA:IEA sodium:potassium-exchanging ATPase activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0005768 IEA endosome
GO:0005886 IDA plasma membrane
GO:0005890 IDA sodium:potassium-exchanging ATPase complex
GO:0005901 IEA caveola
GO:0006754 IEA ATP biosynthetic process
GO:0006813 NAS:IEA potassium ion transport
GO:0006814 NAS:IEA sodium ion transport
GO:0006883 IDA cellular sodium ion homeostasis
GO:0006937 IEA regulation of muscle contraction
GO:0006940 IEA regulation of smooth muscle contraction
GO:0006942 NAS regulation of striated muscle contraction
GO:0008217 IEA regulation of blood pressure
GO:0008344 IEA adult locomotory behavior
GO:0008542 IEA visual learning
GO:0010107 IDA potassium ion import
GO:0010881 TAS regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0015077 IEA monovalent inorganic cation transmembrane transporter activity
GO:0015672 IEA monovalent inorganic cation transport
GO:0015991 IEA ATP hydrolysis coupled proton transport
GO:0016021 IEA integral component of membrane
GO:0019229 IEA regulation of vasoconstriction
GO:0019829 IEA cation-transporting ATPase activity
GO:0030007 IDA cellular potassium ion homeostasis
GO:0030315 IEA T-tubule
GO:0031982 IDA vesicle
GO:0034220 TAS ion transmembrane transport
GO:0035094 IEA response to nicotine
GO:0036376 IDA sodium ion export from cell
GO:0040011 IEA locomotion
GO:0042383 IEA sarcolemma
GO:0043005 IEA neuron projection
GO:0043197 IEA dendritic spine
GO:0045202 IEA synapse
GO:0045822 IEA negative regulation of heart contraction
GO:0045988 IEA negative regulation of striated muscle contraction
GO:0046872 IEA metal ion binding
GO:0051087 IPI chaperone binding
GO:0051481 IEA negative regulation of cytosolic calcium ion concentration
GO:0055085 TAS transmembrane transport
GO:0055119 TAS relaxation of cardiac muscle
GO:0060048 TAS cardiac muscle contraction
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071383 IDA cellular response to steroid hormone stimulus
GO:0086004 IEA regulation of cardiac muscle cell contraction
GO:0086012 TAS membrane depolarization during cardiac muscle cell action potential
GO:0086064 TAS cell communication by electrical coupling involved in cardiac conduction
GO:0098655 IEA cation transmembrane transport
GO:1903416 IC response to glycoside
GO:1990239 IDA steroid hormone binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010472 atp1a2a ATPase, Na+/K+ transporting, alpha 2a polypeptide protein_coding Danio_rerio
ENSMUSG00000007097 Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide protein_coding Mus_musculus

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