C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hepatocyte growth factor (hepapoietin A; scatter factor)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000019991 HGF 9606 - 7:81699006-81770438 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000222390 HGF-001 81699006-81770198 protein_coding
  ENST00000354224 HGF-201 81755121-81769971 protein_coding
  ENST00000412881 HGF-008 81757246-81770398 protein_coding
  ENST00000421558 HGF-007 81758704-81770438 protein_coding
  ENST00000423064 HGF-004 81750889-81770105 protein_coding
  ENST00000444829 HGF-003 81742691-81770031 protein_coding
  ENST00000453018 HGF-006 81756986-81762996 protein_coding
  ENST00000453411 HGF-002 81742732-81770014 protein_coding
  ENST00000457544 HGF-005 81702581-81770048 protein_coding
  ENST00000465234 HGF-009 81751916-81769999 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000222390ENST00000354224ENST00000423064ENST00000444829ENST00000457544
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000222390 N/A 0.641±0.00 0.921±0.00 0.150±0.00 0.393±0.00 N/A 0.251±0.00 0.541±0.00 1.911±0.00 N/A N/A 0.323±0.18 10.140±2.44 N/A
ENST00000354224 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.415±0.00 N/A N/A
ENST00000423064 N/A N/A N/A 0.389±0.00 N/A N/A N/A N/A N/A N/A 0.098±0.00 0.152±0.00 N/A 0.198±0.00
ENST00000444829 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.503±0.00 N/A N/A N/A
ENST00000457544 0.443±0.00 N/A 0.848±0.00 0.453±0.07 1.070±0.00 0.936±0.00 N/A 2.226±0.00 3.406±0.00 5.484±0.00 N/A 0.327±0.00 N/A 0.435±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00052I CIL_00052I_0003 CGP 7:81699006-82443798

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IEA activation of MAPK activity
GO:0000902 IEA cell morphogenesis
GO:0001837 TAS epithelial to mesenchymal transition
GO:0001889 IEA liver development
GO:0002576 TAS platelet degranulation
GO:0003824 IEA catalytic activity
GO:0004252 IEA serine-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005615 IEA extracellular space
GO:0006508 IEA proteolysis
GO:0007067 NAS mitotic nuclear division
GO:0007596 TAS blood coagulation
GO:0008083 NAS growth factor activity
GO:0008283 IEA cell proliferation
GO:0014068 IDA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 IDA membrane
GO:0030168 TAS platelet activation
GO:0030212 IEA hyaluronan metabolic process
GO:0030335 IDA positive regulation of cell migration
GO:0031093 TAS platelet alpha granule lumen
GO:0031100 IEA organ regeneration
GO:0031643 IEA positive regulation of myelination
GO:0035729 IDA cellular response to hepatocyte growth factor stimulus
GO:0042056 IDA chemoattractant activity
GO:0042802 IPI identical protein binding
GO:0043066 IEA negative regulation of apoptotic process
GO:0043154 IDA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045669 NAS positive regulation of osteoblast differentiation
GO:0045766 IEA positive regulation of angiogenesis
GO:0045944 NAS positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IEA protein heterodimerization activity
GO:0048012 IDA hepatocyte growth factor receptor signaling pathway
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 IDA positive chemotaxis
GO:0051450 IEA myoblast proliferation
GO:0060326 IDA cell chemotaxis
GO:0060665 IDA regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0070572 IEA positive regulation of neuron projection regeneration
GO:0090201 IDA negative regulation of release of cytochrome c from mitochondria
GO:1901299 IDA negative regulation of hydrogen peroxide-mediated programmed cell death
GO:1902042 IEA negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000573 IDA positive regulation of DNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000045544 hgfa hepatocyte growth factor a protein_coding Danio_rerio
ENSDARG00000063316 HGF (2 of 2) hepatocyte growth factor (hepapoietin A; scatter factor) protein_coding Danio_rerio
ENSMUSG00000028864 Hgf hepatocyte growth factor protein_coding Mus_musculus

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