C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000020922 MRE11A 9606 - 11:94415578-94493908 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000323929 MRE11A-001 94415578-94493908 protein_coding
  ENST00000323977 MRE11A-002 94419876-94493874 protein_coding
  ENST00000393241 MRE11A-006 94419878-94493848 protein_coding
  ENST00000407439 MRE11A-004 94419866-94493843 protein_coding
  ENST00000535120 MRE11A-009 94445739-94447300 retained_intron
  ENST00000536144 MRE11A-011 94483770-94493813 processed_transcript
  ENST00000536754 MRE11A-007 94479695-94493885 protein_coding
  ENST00000538923 MRE11A-008 94479743-94493812 protein_coding
  ENST00000540013 MRE11A-005 94475216-94493834 protein_coding
  ENST00000541157 MRE11A-010 94478761-94493849 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLungMuscleOvaryPlacentaTestisENST00000323929ENST00000323977ENST00000393241ENST00000407439ENST00000540013
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Lung Muscle Ovary Placenta Testis
ENST00000323929 1.200±0.00 N/A 1.009±0.00 0.313±0.00 1.802±0.00 1.018±0.50 0.689±0.25 0.212±0.00 N/A N/A 1.478±0.45 0.859±0.03 1.793±0.63
ENST00000323977 N/A N/A 0.817±0.00 N/A 3.073±0.00 N/A 0.719±0.00 1.067±0.00 2.077±0.79 0.854±0.00 3.661±1.71 1.890±0.59 3.519±0.04
ENST00000393241 N/A 1.829±0.00 N/A 1.151±0.14 1.688±0.00 2.243±0.41 0.461±0.00 N/A N/A N/A 2.289±0.00 1.560±0.00 N/A
ENST00000407439 N/A N/A N/A 0.885±0.00 N/A N/A N/A 0.596±0.00 1.775±0.00 N/A N/A N/A N/A
ENST00000540013 N/A N/A N/A N/A N/A N/A N/A 1.211±0.00 N/A N/A 5.126±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000014 TAS single-stranded DNA endodeoxyribonuclease activity
GO:0000019 TAS regulation of mitotic recombination
GO:0000723 IBA telomere maintenance
GO:0000724 TAS double-strand break repair via homologous recombination
GO:0000737 TAS DNA catabolic process, endonucleolytic
GO:0000781 IDA chromosome, telomeric region
GO:0000785 IBA chromatin
GO:0003677 IDA DNA binding
GO:0003690 TAS double-stranded DNA binding
GO:0004003 IMP ATP-dependent DNA helicase activity
GO:0004518 TAS nuclease activity
GO:0004519 IBA:IEA endonuclease activity
GO:0004520 TAS endodeoxyribonuclease activity
GO:0004527 IEA exonuclease activity
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0006259 IEA DNA metabolic process
GO:0006281 TAS DNA repair
GO:0006284 IBA base-excision repair
GO:0006289 IBA nucleotide-excision repair
GO:0006302 IBA:IEA double-strand break repair
GO:0006303 TAS double-strand break repair via nonhomologous end joining
GO:0006310 TAS DNA recombination
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0007004 TAS telomere maintenance via telomerase
GO:0007062 IMP sister chromatid cohesion
GO:0007095 IEA mitotic G2 DNA damage checkpoint
GO:0007129 IEA synapsis
GO:0007131 TAS reciprocal meiotic recombination
GO:0008022 IPI protein C-terminus binding
GO:0008283 IEA cell proliferation
GO:0008408 IBA 3'-5' exonuclease activity
GO:0016787 IEA hydrolase activity
GO:0030145 IEA manganese ion binding
GO:0030870 NAS Mre11 complex
GO:0031573 IBA intra-S DNA damage checkpoint
GO:0031954 IDA positive regulation of protein autophosphorylation
GO:0032481 TAS positive regulation of type I interferon production
GO:0032508 IMP DNA duplex unwinding
GO:0032876 IMP negative regulation of DNA endoreduplication
GO:0033674 IDA positive regulation of kinase activity
GO:0035861 IDA site of double-strand break
GO:0045087 TAS innate immune response
GO:0051276 IEA chromosome organization
GO:0051321 IEA meiotic cell cycle
GO:0090305 IEA:IBA nucleic acid phosphodiester bond hydrolysis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000031928 Mre11a meiotic recombination 11 homolog A (S. cerevisiae) protein_coding Mus_musculus

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