C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000323929 MRE11A-001 ENSG00000020922 9606 - 11:94415578-94493908 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyOvaryPlacentaTestisENST00000323929
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Ovary Placenta Testis
ENST00000323929 1.200±0.00 1.009±0.00 0.313±0.00 1.802±0.00 1.018±0.50 0.689±0.25 0.212±0.00 1.478±0.45 0.859±0.03 1.793±0.63

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000014 TAS single-stranded DNA endodeoxyribonuclease activity
GO:0000019 TAS regulation of mitotic recombination
GO:0000723 IBA telomere maintenance
GO:0000724 TAS double-strand break repair via homologous recombination
GO:0000737 TAS DNA catabolic process, endonucleolytic
GO:0000781 IDA chromosome, telomeric region
GO:0000785 IBA chromatin
GO:0003677 IDA DNA binding
GO:0003690 TAS double-stranded DNA binding
GO:0004003 IMP ATP-dependent DNA helicase activity
GO:0004518 TAS nuclease activity
GO:0004519 IBA:IEA endonuclease activity
GO:0004520 TAS endodeoxyribonuclease activity
GO:0004527 IEA exonuclease activity
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0006259 IEA DNA metabolic process
GO:0006281 TAS DNA repair
GO:0006284 IBA base-excision repair
GO:0006289 IBA nucleotide-excision repair
GO:0006302 IBA:IEA double-strand break repair
GO:0006303 TAS double-strand break repair via nonhomologous end joining
GO:0006310 TAS DNA recombination
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0007004 TAS telomere maintenance via telomerase
GO:0007062 IMP sister chromatid cohesion
GO:0007095 IEA mitotic G2 DNA damage checkpoint
GO:0007129 IEA synapsis
GO:0007131 TAS reciprocal meiotic recombination
GO:0008022 IPI protein C-terminus binding
GO:0008283 IEA cell proliferation
GO:0008408 IBA 3'-5' exonuclease activity
GO:0016787 IEA hydrolase activity
GO:0030145 IEA manganese ion binding
GO:0030870 NAS Mre11 complex
GO:0031573 IBA intra-S DNA damage checkpoint
GO:0031954 IDA positive regulation of protein autophosphorylation
GO:0032481 TAS positive regulation of type I interferon production
GO:0032508 IMP DNA duplex unwinding
GO:0032876 IMP negative regulation of DNA endoreduplication
GO:0033674 IDA positive regulation of kinase activity
GO:0035861 IDA site of double-strand break
GO:0045087 TAS innate immune response
GO:0051276 IEA chromosome organization
GO:0090305 IEA:IBA nucleic acid phosphodiester bond hydrolysis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000034405 Mre11a-001 protein_coding Mus_musculus 0 2049
ENSMUST00000115632 Mre11a-002 protein_coding Mus_musculus 0 1131
ENSMUST00000147305 Mre11a-003 protein_coding Mus_musculus 0 721
ENSMUST00000136568 Mre11a-004 protein_coding Mus_musculus 0 392
ENSMUST00000147676 Mre11a-005 protein_coding Mus_musculus 0 211
ENSMUST00000165682 Rasl12-202 protein_coding Mus_musculus 0.00000006 66
ENSMUST00000120488 Klhl22-001 protein_coding Mus_musculus 0.0000002 64
ENSMUST00000123200 Paqr6-004 retained_intron Mus_musculus 0.0000002 64

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