C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glutamate-cysteine ligase, modifier subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000023909 GCLM 9606 - 1:93885205-93909456 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000370238 GCLM-001 93885205-93909410 protein_coding
  ENST00000462183 GCLM-003 93904266-93908924 processed_transcript
  ENST00000467772 GCLM-002 93894644-93908790 processed_transcript
  ENST00000615724 GCLM-201 93887034-93909456 protein_coding
  ENST00000619076 GCLM-202 93887034-93909456 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000370238ENST00000467772ENST00000615724ENST00000619076
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000370238 1.911±0.00 1.072±0.00 2.078±0.00 1.254±0.69 1.011±0.37 0.490±0.00 5.601±0.00 2.790±1.82 N/A 1.381±0.00 1.873±0.47 1.504±1.44 1.152±0.74
ENST00000467772 4.112±0.00 N/A N/A 1.456±0.00 N/A N/A N/A N/A N/A N/A N/A 3.549±0.00 0.851±0.00
ENST00000615724 1.289±0.00 0.480±0.00 0.930±0.51 N/A N/A N/A 2.722±0.00 0.294±0.00 0.631±0.00 N/A N/A N/A 0.608±0.35
ENST00000619076 N/A N/A 0.618±0.00 1.329±0.00 0.859±0.00 0.260±0.00 1.199±0.00 N/A N/A 0.716±0.00 0.611±0.00 1.465±0.19 0.418±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009DH CIL_0009DH_0001 VISTA 1:93546220-94147690
CIL_0009DJ CIL_0009DJ_0001 VISTA 1:93815311-94417966

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000096 TAS sulfur amino acid metabolic process
GO:0004357 IMP glutamate-cysteine ligase activity
GO:0005829 NAS cytosol
GO:0006534 IEA cysteine metabolic process
GO:0006536 IDA glutamate metabolic process
GO:0006749 IEA glutathione metabolic process
GO:0006750 IEA glutathione biosynthetic process
GO:0006805 TAS xenobiotic metabolic process
GO:0006979 IDA response to oxidative stress
GO:0008637 IEA apoptotic mitochondrial changes
GO:0017109 IEA glutamate-cysteine ligase complex
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0035226 IPI glutamate-cysteine ligase catalytic subunit binding
GO:0035229 IEA positive regulation of glutamate-cysteine ligase activity
GO:0042493 IDA response to drug
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0046982 IEA protein heterodimerization activity
GO:0050880 IMP regulation of blood vessel size
GO:0051409 IEA response to nitrosative stress
GO:0051900 IEA regulation of mitochondrial depolarization
GO:1901687 TAS glutathione derivative biosynthetic process
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018953 gclm glutamate-cysteine ligase, modifier subunit protein_coding Danio_rerio
ENSMUSG00000028124 Gclm glutamate-cysteine ligase, modifier subunit protein_coding Mus_musculus

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