C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glutamate-cysteine ligase, modifier subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000028124 Gclm 10090 + 3:122245557-122269984 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000029769 Gclm-001 122245557-122269984 protein_coding
  ENSMUST00000137540 Gclm-003 122245712-122256971 processed_transcript
  ENSMUST00000149983 Gclm-002 122255587-122266503 protein_coding
  ENSMUST00000176445 Gclm-005 122246081-122265225 protein_coding
  ENSMUST00000176761 Gclm-004 122261779-122264908 retained_intron
  ENSMUST00000178826 Gclm-201 122245668-122266435 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000029769ENSMUST00000137540ENSMUST00000149983ENSMUST00000176761ENSMUST00000178826
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000029769 3.491±0.87 13.523±2.48 8.519±0.01 3.164±0.49 5.371±3.37 7.161±1.09 1.263±0.32 21.560±6.54 20.752±4.67 6.276±2.10 1.231±0.50 8.201±4.14 4.916±3.37 2.067±1.12
ENSMUST00000137540 5.307±1.47 48.824±20.07 N/A N/A 25.105±11.08 60.288±3.45 N/A 45.379±30.86 46.522±17.74 20.892±0.00 N/A 23.373±6.26 N/A N/A
ENSMUST00000149983 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 14.181±0.00 3.985±0.00
ENSMUST00000176761 N/A N/A N/A 22.502±0.00 N/A N/A N/A N/A N/A N/A N/A 27.233±0.00 47.239±14.33 13.777±0.00
ENSMUST00000178826 8.482±1.04 N/A 17.016±1.47 5.502±0.00 11.342±5.53 N/A 3.742±0.86 40.772±5.40 41.350±17.36 N/A 7.257±1.17 11.704±2.02 17.445±7.39 8.650±2.05

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009DI CIL_0009DI_0002 VISTA 3:121653542-122254391
CIL_0009DJ CIL_0009DJ_0002 VISTA 3:121747471-122349247
CIL_0009DH CIL_0009DH_0002 VISTA 3:121992915-122594267
CIL_00005U CIL_00005U_0002 CGP 3:122245557-122285269

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004357 ISS glutamate-cysteine ligase activity
GO:0006534 IMP cysteine metabolic process
GO:0006536 ISS glutamate metabolic process
GO:0006749 IMP glutathione metabolic process
GO:0006750 ISS glutathione biosynthetic process
GO:0006979 ISS response to oxidative stress
GO:0008637 IGI apoptotic mitochondrial changes
GO:0017109 IDA glutamate-cysteine ligase complex
GO:0035226 ISS glutamate-cysteine ligase catalytic subunit binding
GO:0035229 IDA positive regulation of glutamate-cysteine ligase activity
GO:0042493 ISS response to drug
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0046982 IPI protein heterodimerization activity
GO:0050880 ISS regulation of blood vessel size
GO:0051409 IEA response to nitrosative stress
GO:0051900 IGI regulation of mitochondrial depolarization
GO:2001237 IGI negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018953 gclm glutamate-cysteine ligase, modifier subunit protein_coding Danio_rerio
ENSG00000023909 GCLM glutamate-cysteine ligase, modifier subunit protein_coding Homo_sapiens

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