C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: glutamate-cysteine ligase, modifier subunit
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000370238 GCLM-001 ENSG00000023909 9606 - 1:93885205-93909410 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverMuscleOvaryPlacentaTestisENST00000370238
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Muscle Ovary Placenta Testis
ENST00000370238 1.911±0.00 1.072±0.00 2.078±0.00 1.254±0.69 1.011±0.37 0.490±0.00 5.601±0.00 2.790±1.82 1.381±0.00 1.873±0.47 1.504±1.44 1.152±0.74

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009DH CIL_0009DH_0001 VISTA 1:93546220-94147690
CIL_0009DJ CIL_0009DJ_0001 VISTA 1:93815311-94417966

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000096 TAS sulfur amino acid metabolic process
GO:0004357 IMP glutamate-cysteine ligase activity
GO:0005829 NAS cytosol
GO:0006534 IEA cysteine metabolic process
GO:0006536 IDA glutamate metabolic process
GO:0006749 IEA glutathione metabolic process
GO:0006750 IEA glutathione biosynthetic process
GO:0006805 TAS xenobiotic metabolic process
GO:0006979 IDA response to oxidative stress
GO:0008637 IEA apoptotic mitochondrial changes
GO:0017109 IEA glutamate-cysteine ligase complex
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0035226 IPI glutamate-cysteine ligase catalytic subunit binding
GO:0035229 IEA positive regulation of glutamate-cysteine ligase activity
GO:0042493 IDA response to drug
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0046982 IEA protein heterodimerization activity
GO:0050880 IMP regulation of blood vessel size
GO:0051409 IEA response to nitrosative stress
GO:0051900 IEA regulation of mitochondrial depolarization
GO:1901687 TAS glutathione derivative biosynthetic process
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000029769 Gclm-001 protein_coding Mus_musculus 0 1190
ENSMUST00000178826 Gclm-201 protein_coding Mus_musculus 0 1155
ENSMUST00000176445 Gclm-005 protein_coding Mus_musculus 0 806
ENSMUST00000176761 Gclm-004 retained_intron Mus_musculus 0 562
ENSMUST00000149983 Gclm-002 protein_coding Mus_musculus 0 532
ENSMUST00000137540 Gclm-003 processed_transcript Mus_musculus 0 337

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