C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000034152 MAP2K3 9606 + 17:21284672-21315240 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000316920 MAP2K3-013 21288046-21314310 protein_coding
  ENST00000342679 MAP2K3-001 21284672-21315240 protein_coding
  ENST00000361818 MAP2K3-201 21288036-21315213 protein_coding
  ENST00000395491 MAP2K3-002 21284672-21315213 nonsense_mediated_decay
  ENST00000477540 MAP2K3-009 21311687-21314432 retained_intron
  ENST00000479129 MAP2K3-006 21284711-21300648 nonsense_mediated_decay
  ENST00000483928 MAP2K3-007 21284711-21298444 nonsense_mediated_decay
  ENST00000496046 MAP2K3-004 21284822-21315228 nonsense_mediated_decay
  ENST00000526076 MAP2K3-016 21288036-21303234 protein_coding
  ENST00000527123 MAP2K3-014 21312142-21313886 protein_coding
  ENST00000529517 MAP2K3-011 21284710-21296143 protein_coding
  ENST00000534743 MAP2K3-010 21284710-21291717 processed_transcript
  ENST00000583508 MAP2K3-017 21284711-21300917 retained_intron
  ENST00000613338 MAP2K3-202 21291469-21314965 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000316920ENST00000342679ENST00000361818ENST00000395491ENST00000477540ENST00000496046ENST00000526076ENST00000527123ENST00000613338
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000316920 10.474±0.00 N/A N/A N/A 7.298±0.00 3.726±0.00 N/A N/A N/A N/A N/A 7.955±0.00 13.809±0.00 1.842±0.43
ENST00000342679 20.349±0.00 6.059±0.00 0.857±0.00 3.074±0.00 9.846±0.00 2.526±0.08 3.132±2.92 7.535±0.00 2.158±1.06 15.724±15.06 16.213±12.78 11.199±5.61 18.484±6.61 3.434±0.62
ENST00000361818 5.756±0.00 18.755±0.00 0.290±0.00 2.182±0.00 9.877±0.00 N/A 5.115±0.00 5.225±3.26 15.344±0.00 34.171±0.00 17.097±0.00 11.578±0.93 22.469±4.71 4.968±0.00
ENST00000395491 N/A N/A N/A N/A N/A N/A N/A 2.053±0.00 N/A N/A N/A N/A N/A N/A
ENST00000477540 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.767±0.00 N/A N/A
ENST00000496046 N/A N/A N/A 1.005±0.00 0.559±0.00 N/A 0.712±0.00 3.579±0.00 N/A N/A 4.322±0.00 N/A N/A N/A
ENST00000526076 N/A N/A N/A N/A 2.718±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 1.547±0.00
ENST00000527123 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.434±0.00 N/A N/A N/A N/A
ENST00000613338 N/A N/A N/A 1.549±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00013Z CIL_00013Z_0001 CGP 17:21238870-21315240
CIL_000142 CIL_000142_0001 CGP 17:21284672-21419872

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000187 TAS activation of MAPK activity
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004708 IEA MAP kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0006954 IEA inflammatory response
GO:0007165 TAS signal transduction
GO:0008152 IEA metabolic process
GO:0016020 IDA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019901 IPI protein kinase binding
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042035 IEA regulation of cytokine biosynthetic process
GO:0045087 TAS innate immune response
GO:0045860 IDA positive regulation of protein kinase activity
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0051403 TAS stress-activated MAPK cascade
GO:0060048 IEA cardiac muscle contraction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000018932 Map2k3 mitogen-activated protein kinase kinase 3 protein_coding Mus_musculus

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