C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: mitogen-activated protein kinase kinase 3
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000342679 MAP2K3-001 ENSG00000034152 9606 + 17:21284672-21315240 protein_coding

Homo sapiens EnsemblGRCh38

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Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000342679
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000342679 20.349±0.00 6.059±0.00 0.857±0.00 3.074±0.00 9.846±0.00 2.526±0.08 3.132±2.92 7.535±0.00 2.158±1.06 15.724±15.06 16.213±12.78 11.199±5.61 18.484±6.61 3.434±0.62

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00013Z CIL_00013Z_0001 CGP 17:21238870-21315240
CIL_000142 CIL_000142_0001 CGP 17:21284672-21419872

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000187 TAS activation of MAPK activity
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004708 IEA MAP kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0006954 IEA inflammatory response
GO:0007165 TAS signal transduction
GO:0016020 IDA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019901 IPI protein kinase binding
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042035 IEA regulation of cytokine biosynthetic process
GO:0045087 TAS innate immune response
GO:0045860 IDA positive regulation of protein kinase activity
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0051403 TAS stress-activated MAPK cascade
GO:0060048 IEA cardiac muscle contraction

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000019076 Map2k3-001 protein_coding Mus_musculus 0 1515
ENSMUST00000145828 Map2k3-003 retained_intron Mus_musculus 0 1077
ENSMUST00000117669 Gm12792-001 processed_pseudogene Mus_musculus 0 737
ENSMUST00000130269 Map2k3-002 nonsense_mediated_decay Mus_musculus 0 730
ENSMUST00000126043 Map2k3-004 processed_transcript Mus_musculus 0 710
ENSMUST00000020949 Map2k6-001 protein_coding Mus_musculus 0 492
ENSMUST00000146540 Map2k6-005 processed_transcript Mus_musculus 0 486
ENSMUST00000100260 Map2k6-003 protein_coding Mus_musculus 0 486
ENSMUST00000146084 Map2k6-002 processed_transcript Mus_musculus 0 424
ENSMUST00000133920 Map2k6-004 processed_transcript Mus_musculus 0 327

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