C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000018932 Map2k3 10090 + 11:60932033-60952811 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000019076 Map2k3-001 60932033-60952811 protein_coding
  ENSMUST00000126043 Map2k3-004 60941880-60946771 processed_transcript
  ENSMUST00000130269 Map2k3-002 60932066-60952794 nonsense_mediated_decay
  ENSMUST00000137609 Map2k3-006 60950662-60951821 retained_intron
  ENSMUST00000137739 Map2k3-005 60932054-60942116 retained_intron
  ENSMUST00000145828 Map2k3-003 60932054-60947591 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000019076ENSMUST00000126043ENSMUST00000130269ENSMUST00000137739ENSMUST00000145828
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000019076 17.626±4.63 15.838±2.67 19.089±0.76 3.881±0.63 18.196±11.45 17.093±4.59 20.385±3.42 15.053±2.77 22.152±13.25 15.836±4.91 66.984±8.06 13.787±3.97 27.427±5.80 14.736±4.45
ENSMUST00000126043 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 24.571±0.00 6.541±0.00
ENSMUST00000130269 N/A 10.900±4.59 N/A 1.075±0.43 5.520±1.73 4.955±1.80 N/A 2.460±0.00 5.555±1.77 4.014±0.95 N/A 1.657±0.00 N/A 1.502±0.00
ENSMUST00000137739 N/A 28.868±2.42 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000145828 N/A N/A N/A 1.246±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00013Z CIL_00013Z_0002 CGP 11:60902246-60952811
CIL_000142 CIL_000142_0002 CGP 11:60932033-61071131

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IMP MAPK cascade
GO:0000187 IMP activation of MAPK activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004708 IMP MAP kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0006954 IMP inflammatory response
GO:0016020 IEA membrane
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019901 IPI protein kinase binding
GO:0042035 IMP regulation of cytokine biosynthetic process
GO:0045860 IEA positive regulation of protein kinase activity
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0060048 IMP cardiac muscle contraction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000034152 MAP2K3 mitogen-activated protein kinase kinase 3 protein_coding Homo_sapiens

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