C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: excision repair cross-complementation group 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000049167 ERCC8 9606 - 5:60873831-60945073 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000265038 ERCC8-001 60873832-60945051 protein_coding
  ENST00000381118 ERCC8-003 60873831-60945051 nonsense_mediated_decay
  ENST00000439176 ERCC8-005 60902482-60945073 protein_coding
  ENST00000462279 ERCC8-004 60873834-60907523 processed_transcript
  ENST00000477893 ERCC8-006 60917963-60945059 retained_intron
  ENST00000484330 ERCC8-007 60898324-60918613 processed_transcript
  ENST00000495985 ERCC8-008 60898314-60918559 processed_transcript
  ENST00000497892 ERCC8-002 60903360-60945051 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000265038ENST00000381118ENST00000439176ENST00000462279ENST00000477893ENST00000495985ENST00000497892
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000265038 0.485±0.00 0.397±0.00 0.798±0.00 1.339±0.00 0.307±0.00 1.120±0.00 1.921±0.00 0.688±0.19 0.209±0.00 0.479±0.00 1.374±0.34 2.222±0.19 3.144±0.90
ENST00000381118 N/A N/A 0.306±0.00 N/A N/A N/A N/A N/A N/A N/A 0.471±0.00 N/A N/A
ENST00000439176 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.266±0.00 N/A
ENST00000462279 N/A N/A N/A 0.192±0.00 N/A N/A 0.279±0.00 N/A 0.321±0.00 N/A N/A N/A 0.355±0.00
ENST00000477893 N/A N/A N/A N/A N/A N/A 1.016±0.00 N/A N/A N/A 0.747±0.00 N/A N/A
ENST00000495985 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.447±0.00 N/A N/A N/A
ENST00000497892 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.977±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000109 IDA nucleotide-excision repair complex
GO:0000209 IDA protein polyubiquitination
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0006281 TAS DNA repair
GO:0006283 IDA transcription-coupled nucleotide-excision repair
GO:0006289 IMP nucleotide-excision repair
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0006979 IDA response to oxidative stress
GO:0009411 IDA response to UV
GO:0010165 IEA response to X-ray
GO:0016363 IDA nuclear matrix
GO:0031464 IDA Cul4A-RING E3 ubiquitin ligase complex
GO:0032403 IDA protein complex binding
GO:0043161 IDA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043234 IDA protein complex
GO:0045739 IMP positive regulation of DNA repair
GO:0051865 IDA protein autoubiquitination

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000069283 ercc8 excision repair cross-complementing rodent repair deficiency, complementation group 8 protein_coding Danio_rerio
ENSMUSG00000021694 Ercc8 excision repaiross-complementing rodent repair deficiency, complementation group 8 protein_coding Mus_musculus

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