C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: excision repaiross-complementing rodent repair deficiency, complementation group 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021694 Ercc8 10090 + 13:108158731-108195364 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000054835 Ercc8-001 108158738-108194985 protein_coding
  ENSMUST00000120672 Ercc8-003 108158738-108174598 protein_coding
  ENSMUST00000123138 Ercc8-009 108158804-108178664 nonsense_mediated_decay
  ENSMUST00000123182 Ercc8-008 108158775-108173104 nonsense_mediated_decay
  ENSMUST00000123657 Ercc8-002 108158731-108195364 nonsense_mediated_decay
  ENSMUST00000129117 Ercc8-004 108158738-108177248 nonsense_mediated_decay
  ENSMUST00000133957 Ercc8-010 108158803-108183921 nonsense_mediated_decay
  ENSMUST00000137425 Ercc8-007 108158738-108163664 retained_intron
  ENSMUST00000142931 Ercc8-006 108158771-108194977 nonsense_mediated_decay
  ENSMUST00000152634 Ercc8-005 108158754-108194985 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000054835ENSMUST00000123138ENSMUST00000123182ENSMUST00000123657ENSMUST00000129117ENSMUST00000142931ENSMUST00000152634
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000054835 2.278±0.68 1.565±0.37 1.322±0.08 5.136±0.03 2.579±0.72 2.671±0.48 1.706±0.45 2.128±0.42 2.565±1.29 3.156±1.30 1.346±0.32 3.622±1.49 2.477±1.25 10.746±4.65
ENSMUST00000123138 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.021±0.00 N/A N/A
ENSMUST00000123182 N/A N/A N/A 5.185±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 3.233±0.93 10.756±0.00
ENSMUST00000123657 0.748±0.00 2.808±0.00 N/A 1.249±0.00 0.458±0.02 0.408±0.00 N/A N/A N/A 1.200±0.00 0.248±0.06 N/A 0.465±0.00 N/A
ENSMUST00000129117 N/A 0.819±0.23 N/A N/A N/A 0.678±0.00 N/A N/A N/A N/A N/A 0.881±0.30 0.289±0.11 0.445±0.00
ENSMUST00000142931 N/A N/A N/A N/A N/A N/A 0.357±0.00 N/A 0.606±0.00 N/A N/A 0.712±0.00 N/A N/A
ENSMUST00000152634 1.342±0.53 0.862±0.40 1.023±0.27 3.188±0.26 1.220±0.32 0.806±0.08 0.686±0.02 1.056±0.27 1.028±0.39 1.205±0.28 0.586±0.00 1.512±0.53 0.981±0.12 4.744±0.26

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004LG CIL_0004LG_0002 CGP 13:108052590-108195364
CIL_0001YO CIL_0001YO_0002 CGP 13:108158731-108287105

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000109 IEA nucleotide-excision repair complex
GO:0000209 IEA protein polyubiquitination
GO:0004842 IEA ubiquitin-protein transferase activity
GO:0005634 IEA nucleus
GO:0006283 IEA transcription-coupled nucleotide-excision repair
GO:0006289 IEA nucleotide-excision repair
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0006979 IEA response to oxidative stress
GO:0009411 IMP response to UV
GO:0010165 IMP response to X-ray
GO:0016363 IEA nuclear matrix
GO:0031464 IEA Cul4A-RING E3 ubiquitin ligase complex
GO:0032403 IEA protein complex binding
GO:0043161 IEA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043234 IEA protein complex
GO:0045739 IEA positive regulation of DNA repair
GO:0051865 IEA protein autoubiquitination

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000069283 ercc8 excision repair cross-complementing rodent repair deficiency, complementation group 8 protein_coding Danio_rerio
ENSG00000049167 ERCC8 excision repair cross-complementation group 8 protein_coding Homo_sapiens

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