C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000051382 PIK3CB 9606 - 3:138652699-138834938 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000289153 PIK3CB-201 138652699-138759359 protein_coding
  ENST00000461451 PIK3CB-003 138755849-138834938 protein_coding
  ENST00000462294 PIK3CB-014 138714660-138742781 protein_coding
  ENST00000462898 PIK3CB-002 138654068-138834917 nonsense_mediated_decay
  ENST00000465581 PIK3CB-008 138759175-138770555 protein_coding
  ENST00000469284 PIK3CB-005 138654020-138712304 nonsense_mediated_decay
  ENST00000473435 PIK3CB-009 138681984-138712253 nonsense_mediated_decay
  ENST00000477593 PIK3CB-001 138654018-138834752 protein_coding
  ENST00000481749 PIK3CB-006 138655088-138707621 retained_intron
  ENST00000483968 PIK3CB-007 138755757-138834833 protein_coding
  ENST00000485060 PIK3CB-010 138683678-138685126 retained_intron
  ENST00000487552 PIK3CB-012 138657283-138663933 retained_intron
  ENST00000493568 PIK3CB-004 138655150-138714715 protein_coding
  ENST00000544716 PIK3CB-202 138654022-138714486 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000289153ENST00000462294ENST00000462898ENST00000469284ENST00000477593ENST00000481749ENST00000493568ENST00000544716
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000289153 N/A N/A 0.528±0.00 N/A 1.678±0.00 N/A 0.200±0.00 N/A N/A 1.012±0.00 N/A N/A N/A N/A
ENST00000462294 N/A N/A N/A N/A 10.135±0.00 N/A N/A N/A N/A 9.692±0.00 N/A N/A N/A N/A
ENST00000462898 N/A N/A N/A 2.758±0.00 1.836±0.00 1.254±0.00 N/A 1.153±0.00 1.611±0.00 0.528±0.00 N/A N/A N/A 0.783±0.00
ENST00000469284 N/A 1.335±0.00 1.878±0.00 3.060±0.40 N/A N/A 0.727±0.00 N/A 1.784±0.00 N/A 0.650±0.00 2.313±0.00 2.832±0.61 2.718±0.00
ENST00000477593 3.863±0.00 1.623±0.00 N/A 3.564±0.69 2.000±0.92 2.655±0.01 2.523±1.75 2.666±1.65 1.236±0.28 1.807±0.08 2.354±0.00 2.003±0.49 3.575±0.97 2.099±0.63
ENST00000481749 N/A N/A N/A N/A N/A N/A N/A N/A 0.874±0.00 N/A N/A N/A N/A N/A
ENST00000493568 N/A N/A 2.824±0.00 N/A N/A 1.285±0.00 2.015±0.00 0.723±0.00 N/A N/A 1.799±0.06 2.705±0.49 8.987±0.00 2.210±0.00
ENST00000544716 2.160±0.00 N/A N/A N/A N/A 2.406±0.00 N/A 4.379±0.00 N/A 1.498±0.00 N/A 1.156±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 TAS activation of MAPK activity
GO:0001952 IEA regulation of cell-matrix adhesion
GO:0005488 IEA binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005829 TAS cytosol
GO:0005886 IBA plasma membrane
GO:0005942 IBA phosphatidylinositol 3-kinase complex
GO:0006644 TAS phospholipid metabolic process
GO:0006661 TAS phosphatidylinositol biosynthetic process
GO:0006874 IEA cellular calcium ion homeostasis
GO:0006914 IEA autophagy
GO:0006935 TAS chemotaxis
GO:0007156 IEA homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007165 NAS signal transduction
GO:0007169 TAS transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0007596 TAS blood coagulation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0010508 TAS positive regulation of autophagy
GO:0014065 TAS phosphatidylinositol 3-kinase signaling
GO:0016301 IEA kinase activity
GO:0016303 IBA 1-phosphatidylinositol-3-kinase activity
GO:0016477 TAS cell migration
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0030168 TAS platelet activation
GO:0035004 TAS phosphatidylinositol 3-kinase activity
GO:0035005 IBA 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0036092 IEA phosphatidylinositol-3-phosphate biosynthetic process
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0040016 IEA embryonic cleavage
GO:0043560 IEA insulin receptor substrate binding
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0046854 IEA phosphatidylinositol phosphorylation
GO:0046934 IBA phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 IEA:TAS phosphatidylinositol-mediated signaling
GO:0050852 TAS T cell receptor signaling pathway
GO:0050900 TAS leukocyte migration
GO:0070527 TAS platelet aggregation
GO:2000369 TAS regulation of clathrin-mediated endocytosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075253 pik3cb phosphoinositide-3-kinase, catalytic, beta polypeptide protein_coding Danio_rerio
ENSMUSG00000032462 Pik3cb phosphatidylinositol 3-kinase, catalytic, beta polypeptide protein_coding Mus_musculus

Loading